Diagnostic accuracy of multiparametric ultrasound in the diagnosis of prostate cancer: systematic review and meta-analysis

作者全名："Tang, Yun; Li, Xingsheng; Jiang, Qing; Zhai, Lingyun"

作者地址："[Tang, Yun; Li, Xingsheng] Chongqing Med Univ, Affiliated Hosp 2, Dept Geriatr Med, Chongqing 400010, Peoples R China; [Tang, Yun] Longmen Hao St Community Hlth Serv Ctr, Chongqing 401336, Peoples R China; [Jiang, Qing; Zhai, Lingyun] Chongqing Med Univ, Affiliated Hosp 2, Dept Urol, Chongqing 400010, Peoples R China"

通信作者："Jiang, Q; Zhai, LY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Urol, Chongqing 400010, Peoples R China."

来源：INSIGHTS INTO IMAGING

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001122480600001

JCR分区：Q1

影响因子：4.1

年份：2023

卷号：14

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：Prostate cancer; Multiparametric ultrasound; Contrast-enhanced; Elastography

摘要："Objectives: Ultrasound (US) technology has recently made advances that have led to the development of modalities including elastography and contrast-enhanced ultrasound. The use of different US modalities in combination may increase the accuracy of PCa diagnosis. This study aims to assess the diagnostic accuracy of multiparametric ultrasound (mpUS) in the PCa diagnosis.Methods: Through September 2023, we searched through Cochrane CENTRAL, PubMed, Embase, Scopus, Web of Science, ClinicalTrial.gov, and Google Scholar for relevant studies. We used standard methods recommended for meta-analyses of diagnostic evaluation. We plot the SROC curve, which stands for summary receiver operating characteristic. To determine how confounding factors affected the results, meta-regression analysis was used.Results: Finally, 1004 patients from 8 studies that were included in this research were examined. The diagnostic odds ratio for PCa was 20 (95% confidence interval (CI), 8-49) and the pooled estimates of mpUS for diagnosis were as follows: sensitivity, 0.88 (95% CI, 0.81-0.93); specificity, 0.72 (95% CI, 0.59-0.83); positive predictive value, 0.75 (95% CI, 0.63-0.87); and negative predictive value, 0.82 (95% CI, 0.71-0.93). The area under the SROC curve was 0.89 (95% CI, 0.86-0.92). There was a significant heterogeneity among the studies (p < 0.01). According to meta-regression, both the sensitivity and specificity of mpUS in the diagnosis of clinically significant PCa (csPCa) were inferior to any PCa.Conclusion: The diagnostic accuracy of mpUS in the diagnosis of PCa is moderate, but the accuracy in the diagnosis of csPCa is significantly lower than any PCa. More relevant research is needed in the future."

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