A Theragnostic HIFU Transducer and System for Inherently Registered Imaging and Therapy
作者全名:"Zhou, Xiaowei; Li, Yanhao; Zhu, Qiaomiao; Luo, Jieyu; Cao, Linna; Quetai, Jiangchu; Li, Faqi; Tang, Meng-Xing; Wang, Zhibiao"
作者地址:"[Zhou, Xiaowei; Li, Yanhao; Zhu, Qiaomiao; Luo, Jieyu; Cao, Linna; Quetai, Jiangchu; Li, Faqi; Wang, Zhibiao] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Engn Med, Chongqing 400016, Peoples R China; [Tang, Meng-Xing] Imperial Coll, Dept Bioengn, London, England"
通信作者:"Li, FQ; Wang, ZB (通讯作者),Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Engn Med, Chongqing 400016, Peoples R China."
来源:IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
ESI学科分类:ENGINEERING
WOS号:WOS:001123725100016
JCR分区:Q2
影响因子:4.4
年份:2023
卷号:70
期号:12
开始页:3413
结束页:3424
文献类型:Article
关键词:Biomedical image processing; Acoustics; Medical treatment; Ultrasonic imaging; Transducers; Vibrations; Surgery; Acoustooptic effects; Dual-mode HIFU system; high intensity focused ultrasound; surgery planning and evaluation; vibro-acoustography imaging
摘要:"Objective: One big challenge with high intensity focused ultrasound (HIFU) is the difficulty in accurate prediction of focal location due to the complex wave propagation in heterogeneous medium even with imaging guidance. This study aims to overcome this by combining therapy and imaging guidance with one single HIFU transducer using the vibro-acoustography (VA) strategy. Methods: Based on the VA imaging method, a HIFU transducer consisting of 8 transmitting elements was proposed for therapy planning, treatment and evaluation. Inherent registration between the therapy and imaging created unique spatial consistence in HIFU transducer's focal region in the above three procedures. Performance of this imaging modality was first evaluated through in-vitro phantoms. In-vitro and ex-vivo experiments were then designed to demonstrate the proposed dual-mode system's ability in conducting accurate thermal ablation. Results: Point spread function of the HIFU-converted imaging system had a full wave half maximum of about 1.2 mm in both directions at a transmitting frequency of 1.2 MHz, which outperformed the conventional ultrasound imaging (3.15 MHz) in in-vitro situation. Image contrast was also tested on the in-vitro phantom. Various geometric patterns could be accurately 'burned out' on the testing objects by the proposed system both in vitro and ex vivo. Conclusion: Implementation of imaging and therapy with one HIFU transducer in this manner is feasible and it has potential as a novel strategy for addressing the long-standing problem in the HIFU therapy, possibly pushing this non-invasive technique forward towards wider clinical applications."
基金机构:National Natural Science Foundation of China
基金资助正文:No Statement Available