Evaluation of the efficacy of gastric lymphoma treated with non-surgical therapy using oral and double contrast-enhanced gastric ultrasonography

作者全名："Wen, Zi-Wei; He, Xue-Mei; Chen, Chong-Qing; Sun, Jing; Yin, Jiang-Yan; Wang, Tian-Tian; Liu, Zi-Yu; Wang, Li; Yang, Nan-Lan"

作者地址："[Wen, Zi-Wei; He, Xue-Mei; Chen, Chong-Qing; Sun, Jing; Yin, Jiang-Yan; Wang, Tian-Tian; Yang, Nan-Lan] Chongqing Med Univ, Affiliated Hosp 1, Dept Ultrasound, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Liu, Zi-Yu] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China; [Wang, Li] Chongqing Med Univ, Affiliated Hosp 1, Dept Hematol, Chongqing, Peoples R China"

通信作者："He, XM (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Ultrasound, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：MEDICAL ULTRASONOGRAPHY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001123894300004

JCR分区：Q3

影响因子：1.7

年份：2023

卷号：25

期号：3

开始页：255

结束页：262

文献类型：Article

关键词：Gastric lymphoma; Efficacy evaluation; Oral contrast-enhanced ultrasound; Double contrast-enhanced ultrasound

摘要："Aim: To investigate the feasibility of assessing the efficacy of non-surgical treatment for gastric lymphoma using oral contrast-enhanced ultrasound (OCEUS) and double contrast-enhanced ultrasound (DCEUS). Material and methods: A total of 27 patients with gastric lymphoma treated nonoperatively were included in this retrospective study. The efficacy was evaluated using OCEUS and CT, respectively, and the results were tested for kappa concordance. Sixteen of the 27 patients underwent multiple DCEUS examinations before and after treatment. Micro-perfusion of the lesion in DCEUS is represented by the Echo Intensity Ratio (EIR), (echo intensity of the lymphoma lesion/echo intensity of the normal gastric wall), and one-way ANOVA was used to compare the differences between groups in EIR values before and after treatment. Results: OCEUS and CT were highly consistent in assessing the efficacy of gastric lymphoma, with a Kappa value of 0.758. During a median follow-up of 8.8 months, there was no statistical difference between the complete remission rate obtained by OCEUS and that obtained by endoscopic and CT (25.93% vs. 44.44%, p=0.154; 25.93% vs. 33.33%, p=0.766). There was also no statistical difference in the time to achieve complete remission using OCEUS assessment and endoscopy and CT (4.71 +/- 1.03 months vs. 6.01 +/- 2.14 months, p=0.088; 4.47 +/- 1.84 months vs. 6.01 +/- 2.14 months p=0.143). The difference in EIR between the groups before treatment and after different numbers of treatments was statistically significant (p<0.05), and post hoc analysis revealed this difference as early as after the second treatment (p<0.05). Conclusions: Transabdominal OCEUS and CT are comparable in the assessment of gastric lymphoma treatment efficacy. DCEUS is a noninvasive, cost-effective, and widely available method for gastric lymphoma therapeutic effect evaluation. Therefore, transabdominal OCEUS and DCEUS have the potential to be used for the early assessment of the efficacy of the non-surgical treatment of gastric lymphoma."

基金机构：Chongqing Municipal Science and Technology Commission [2020FYYX196]; Health Construction Committee [2020FYYX196]

基金资助正文：This work was partly supported by Chongqing Municipal Science and Technology Commission and Health Construction Committee Joint Project (2020FYYX196).