Identification of Immune-Related LncRNA for Predicting Survival in Skin Cutaneous Melanoma

作者全名："Qi, Jiayi; Huang, Xumiao; Lin, Wei; Ao, Yahui; Zhao, Wenting; Cao, Chunhao"

作者地址："[Qi, Jiayi; Cao, Chunhao] Chongqing Med Univ, Chongqing 400016, Peoples R China; [Huang, Xumiao; Zhao, Wenting] Hubei Univ Chinese Med, Wuhan, Peoples R China; [Lin, Wei; Ao, Yahui] Chongqing Med Univ, Affiliated Hosp 1, Dept Integrated Tradit Chinese & Western Med, Chongqing 400016, Peoples R China"

通信作者："Cao, CH (通讯作者)，Chongqing Med Univ, Chongqing 400016, Peoples R China.; Zhao, WT (通讯作者)，Hubei Univ Chinese Med, Wuhan, Peoples R China."

来源：PAKISTAN JOURNAL OF ZOOLOGY

ESI学科分类：PLANT & ANIMAL SCIENCE

WOS号：WOS:001124552200001

JCR分区：Q4

影响因子：0.5

年份：2024

卷号：56

期号：1

开始页：1

结束页：7

文献类型：Article

关键词：Coilia nasus; SSR markers; Transcriptome

摘要："Immune-related lncRNAs (LncRNA) play an essential role in tumorigenesis and progression, and sought to develop an immune-related lncRNA signature to assess the value of immune-related lncRNAs to discover their prognostic values. RNA-seq and clinical information were obtained from the Cancer Genome Atlas (TCGA) database, which aims to screen for immune-associated lncRNAs based on constructing a risk scoring formula. Besides, in virtue of univariate and multivariate Cox regression, immune-associated lncRNA signatures formed its structure. In addition, in virtue of gene ontology (GO) and KEGG pathway enrichment analysis genes were given functional identification. In total, there were 102 differentially expressed immune-related lncRNAs which were identified, and there were four genes (USP30-AS1, U62317.1, ZEB1-AS1 and MIR205HR) which were screened from the gene signature to form a prognostic signature model. Based on the survival analysis results, patients with high-risk scores had poor survival outcomes. To conclude, we constructed a predictive signature of four immune-related lncRNAs, which can provide assistance for prognosis prediction and immunotherapy of SKCM."

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