The functional role of lncRNAs as ceRNAs in both ovarian processes and associated diseases
作者全名："Usman, Muhammad; Li, Ai; Wu, Dan; Yang, Qinyan; Yi, Lin Xiao; He, Guiqiong; Lu, Hong"
作者地址："[Usman, Muhammad] Chongqing Univ Technol, Dept Plast & Reconstruct Surg, Cent Hosp, Gonglian Yicun 1 St lijiatuo, Chongqing 400054, Peoples R China; [Li, Ai] Seventh Peoples Hosp Chongqing, Dept Postdoctoral Res Workstn, Chongqing, Peoples R China; [Wu, Dan] Army Med Univ, Mil Med Univ 3, Southwest Hosp, Clin Med Res Ctr, Chongqing, Peoples R China; [Yang, Qinyan] Chongqing Univ Technol, Dept Anesthesia, Cent Hosp, Gonglian Yicun 1 St lijiatuo, Chongqing 400054, Peoples R China; [Yi, Lin Xiao] Chenjiaqiao Hosp Shapingba Dist Chongqing, Dept Radiol, Chongqing, Peoples R China; [He, Guiqiong] Chongqing Med Univ, Inst Neurosci, Basic Med Coll, Chongqing 400016, Peoples R China; [Lu, Hong] Chongqing Univ Technol, Dept Med Imaging, Cent Hosp, Gonglian Yicun 1 St lijiatuo, Chongqing 400054, Peoples R China"
通信作者："He, GQ (通讯作者)，Chongqing Med Univ, Inst Neurosci, Basic Med Coll, Chongqing 400016, Peoples R China.; Lu, H (通讯作者)，Chongqing Univ Technol, Dept Med Imaging, Cent Hosp, Gonglian Yicun 1 St lijiatuo, Chongqing 400054, Peoples R China."
来源：NON-CODING RNA RESEARCH
ESI学科分类：
WOS号：WOS:001124574100001
JCR分区：Q1
影响因子：5.9
年份：2024
卷号：9
期号：1
开始页：165
结束页：177
文献类型：Review
关键词：Long non-coding RNAs (lncRNAs); Gene expression; Ovarian function; Ovarian biology; Targeted therapies; Reproductive health
摘要："Long non-coding RNAs (lncRNAs) have attracted significant scientific attention due to their central role in regulating gene expression and their profound impact on the intricate mechanisms of ovarian function. These versatile molecules exert their influence through various mechanisms, including the coordination of transcription processes, modulation of post-transcriptional events, and the shaping of epigenetic landscapes. Furthermore, lncRNAs function as competitive endogenous RNAs (ceRNAs), engaging in intricate interactions with microRNAs (miRNAs) to finely adjust the expression of target genes. The intricate lncRNA-miRNA-mRNA network serves as a crucial determinant in governing the multifaceted physiological functions of the ovaries. It holds substantial potential in unraveling the causes and progression of reproductive disorders and, importantly, in identifying new therapeutic targets and diagnostic markers for these conditions. A comprehensive comprehension of lncRNAs and their ceRNA activities within the domain of ovarian biology could potentially lead to groundbreaking advancements in clinical interventions and management strategies. This exploration of lncRNAs and their intricate involvement in the regulatory framework provides an extensive platform for deciphering the complex nature of ovarian physiology and pathology. The ongoing progress in this field, which encompasses in-depth investigations into the functional roles of specific lncRNAs, the elucidation of their complex interactions with miRNAs, and the comprehensive profiling of their expression patterns, holds the promise of making significant contributions to our understanding of ovarian biology and reproductive disorders. Ultimately, these breakthroughs will have wide-ranging translational implications, paving the way for the development of precision therapies and personalized medicine strategies to address the myriad challenges in the realm of reproductive health."
基金机构："Science and Technology Bureau of Banan District, Chongqing [2021-36]; Central Hospital Affiliated to Chongqing University of Technology; Science and Technology Bureau of Banan District, Chongqing [2021-36]; Central Hospital Affiliated to Chongqing University of Technology, Banan district, Chongqing, P.R. China"
基金资助正文："Central Hospital Affiliated to Chongqing University of Technology, The Science and Technology Bureau of Banan District, Chongqing [grant number 2021-36] . Central Hospital Affiliated to Chongqing University of Technology, Gonglian yicun No.1 street lijiatuo, Banan district, Chongqing 400054, P.R. China."
