Non-coding RNA and Drug resistance in cholangiocarcinoma

作者全名："Wu, Zhaowei; Jiang, Shiming; Chen, Yong"

作者地址："[Wu, Zhaowei; Jiang, Shiming; Chen, Yong] Chongqing Med Univ, Affiliated Hosp 1, Hepatobiliary Surg, Med Coll St, Chongqing 404100, Peoples R China"

通信作者："Chen, Y (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Hepatobiliary Surg, Med Coll St, Chongqing 404100, Peoples R China."

来源：NON-CODING RNA RESEARCH

ESI学科分类：　

WOS号：WOS:001124616200001

JCR分区：Q1

影响因子：5.9

年份：2024

卷号：9

期号：1

开始页：194

结束页：202

文献类型：Review

关键词：Cholangiocarcinoma; Drug resistance; ncRNA; miRNA; lncRNA; Circ RNA

摘要："Cholangiocarcinoma is a highly aggressive cancer with a dismal prognosis and limited resectability. Chemotherapy has demonstrated tremendous benefits for patients with advanced and inoperable cancer, but drug resistance poses a significant obstacle. Despite recent progress in cancer therapy, the mechanisms driving drug resistance are multifaceted and not completely comprehended. Non-coding RNA refers to RNA molecules that are endogenous and do not code for proteins. Particularly microRNAs, long non-coding RNAs, circular RNAs, are widely acknowledged to be involved in cancer initiation, proliferation, and metastasis. Recently, evidences suggests that abnormal expression of non-coding RNAs contributes to resistance to different type of cancer therapies in cholangiocarcinoma. This occurs via the rewiring of signaling pathways including the reduction of anticancer drugs, apoptosis, interaction between cholangiocarcinoma and tumor-infiltrating immune cells, and cancer stemness. Thus, our review aims to demonstrate the potential of targeting non-coding RNA to override drug resistance and summarize the molecular mechanisms of how non-coding RNA contributes to drug resistance in cholangiocarcinoma."

基金机构：National Natural Science Foundation of China [81871261]

基金资助正文：This study was funded by the National Natural Science Foundation of China under grants No. 81871261.