Progress in regulating inflammatory biomaterials for intervertebral disc regeneration
作者全名："Xiang, Honglin; Zhao, Weikang; Jiang, Ke; He, Jiangtao; Chen, Lu; Cui, Wenguo; Li, Yuling"
作者地址："[Xiang, Honglin; Jiang, Ke; He, Jiangtao; Chen, Lu; Li, Yuling] North Sichuan Med Coll, Dept Orthopaed, Lab Biol Tissue Engn & Digital Med, Affiliated Hosp, 1 South Maoyuan Rd, Nanchong 637000, Sichuan, Peoples R China; [Cui, Wenguo] Shanghai Jiao Tong Univ, Dept Orthopaed,Ruijin Hosp,Sch Med, Shanghai Inst Traumatol & Orthopaed, Shanghai Key Lab Prevent & Treatment Bone & Joint, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China; [Zhao, Weikang] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, Orthoped Lab, 1 Youyi Rd, Chongqing 400016, Peoples R China"
通信作者："Li, YL (通讯作者)，North Sichuan Med Coll, Dept Orthopaed, Lab Biol Tissue Engn & Digital Med, Affiliated Hosp, 1 South Maoyuan Rd, Nanchong 637000, Sichuan, Peoples R China.; Cui, WG (通讯作者)，Shanghai Jiao Tong Univ, Dept Orthopaed,Ruijin Hosp,Sch Med, Shanghai Inst Traumatol & Orthopaed, Shanghai Key Lab Prevent & Treatment Bone & Joint, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China."
来源：BIOACTIVE MATERIALS
ESI学科分类：
WOS号：WOS:001124886300001
JCR分区：Q1
影响因子：18
年份：2024
卷号：33
期号：
开始页：506
结束页：531
文献类型：Review
关键词：Intervertebral disc; Anti-Inflammation; Biomaterials; Tissue regeneration
摘要："Intervertebral disc degeneration (IVDD) is rising worldwide and leading to significant health issues and financial strain for patients. Traditional treatments for IVDD can alleviate pain but do not reverse disease progression, and surgical removal of the damaged disc may be required for advanced disease. The inflammatory microenvironment is a key driver in the development of disc degeneration. Suitable antiinflammatory substances are critical for controlling inflammation in IVDD. Several treatment options, including glucocorticoids, non-steroidal anti-inflammatory drugs, and biotherapy, are being studied for their potential to reduce inflammation. However, anti-inflammatories often have a short half-life when applied directly and are quickly excreted, thus limiting their therapeutic effects. Biomaterial-based platforms are being explored as anti-inflammation therapeutic strategies for IVDD treatment. This review introduces the pathophysiology of IVDD and discusses anti-inflammatory therapeutics and the components of these unique biomaterial platforms as comprehensive treatment systems. We discuss the strengths, shortcomings, and development prospects for various biomaterials platforms used to modulate the inflammatory microenvironment, thus providing guidance for future breakthroughs in IVDD treatment."
基金机构："National Natural Science Foundation of China [82102578, 82102571]; Special Project for the Central Government to Guide the Development of Local Science and Technology in Sichuan Province [23ZYZYTS0235]; China Postdoctoral Science Foundation [2022M720603, 2022M710564]; Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX0104, CSTB2022NSCQ-MSX0089]; Research Project of Health Commission of Sichuan Province [2023-1601]; Research Project of Nanchong Science and Technology Bureau [22SXJCQN0004]; Research Project of the Affiliated Hospital of North Sichuan Medical College [2022JB008, 2023ZD002]"
基金资助正文："H. Xiang, W. Zhao, K. Jiang contributed equally to this work. This work is supported by the National Natural Science Foundation of China (82102578, 82102571), Special Project for the Central Government to Guide the Development of Local Science and Technology in Sichuan Province (23ZYZYTS0235), China Postdoctoral Science Foundation (2022M720603, 2022M710564), Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0104, CSTB2022NSCQ-MSX0089), Research Project of Health Commission of Sichuan Province (2023-1601), Research Project of Nanchong Science and Technology Bureau (22SXJCQN0004), Research Project of the Affiliated Hospital of North Sichuan Medical College (2022JB008, 2023ZD002). We would also like to acknowledge BioRender, which was used to create a Graphical abstract in this review."
