Potential Role of Intrapulmonary Concomitant Lesions in Differentiating Non-Neoplastic and Neoplastic Ground Glass Nodules

作者全名："Fu, Bin-Jie; Zhang, Xiao-Chuan; Lv, Fa-Jin; Chu, Zhi-Gang"

作者地址："[Fu, Bin-Jie; Zhang, Xiao-Chuan; Lv, Fa-Jin; Chu, Zhi-Gang] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China; [Zhang, Xiao-Chuan] Chonggang Gen Hosp, Dept Radiol, Chongqing, Peoples R China; [Chu, Zhi-Gang] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Chu, ZG (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：JOURNAL OF INFLAMMATION RESEARCH

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001125265400001

JCR分区：Q2

影响因子：4.2

年份：2023

卷号：16

期号：　

开始页：6155

结束页：6166

文献类型：Article

关键词：ground-glass nodule; intrapulmonary concomitant lesion; differential diagnosis; tomography; X-rays

摘要："Purpose: To determine the value of intrapulmonary concomitant lesions in differentiating non-neoplastic and neoplastic ground-glass Patients and Methods: From January 2014 to March 2022, 395 and 583 patients with confirmed non-neoplastic and neoplastic GGNs were retrospectively enrolled. Their clinical and chest CT data were evaluated. The CT features of target GGNs and intrapulmonary concomitant lesions in these two groups were analyzed and compared, and the role of intrapulmonary concomitant lesions in improving differentiation was evaluated. Results: The intrapulmonary concomitant lesions were more common in patients with non-neoplastic GGNs than in those with neoplastic ones (87.88% vs 82.18%, P = 0.015). Specifically, patients with non-neoplastic GGNs had a higher incidence of multiple solid nodules (SNs), patchy ground-glass opacity/consolidation, and fibrosis/calcification in any lung fields (each P < 0.05). Logistic regression analysis indicated that patients < 44 years old, diameter < 7.35 mm, irregular shape, and coarse margin or ill-defined boundary for target GGN, pleural thickening, and concomitant SNs in the same lobe and fibrosis or calcification in any lung field were independent indicators for predicting non-neoplastic GGNs. The AUC of the model for predicting non-neoplastic GGNs increased from 0.894 to 0.926 (sensitivity, 83.10%; specificity, 87.10%) after including the concomitant lesions in the patients' clinical characteristics and CT features of target GGNs (P < 0.0001). Conclusion: Besides the patients' clinical characteristics and CT features of target GGNs, the concomitant multiple SNs in the same lobe and fibrosis/calcification in any lung field should be considered in further differentiating non-neoplastic and neoplastic GGNs."

基金机构：Joint Project of Chongqing Science and Technology Commission and Chongqing Public Health Commission [2022MSXM050]; Senior Medical Talents Program of Chongqing for Young and Middle- aged from Chongqing Health Commission

基金资助正文："This work was supported by the Joint Project of Chongqing Science and Technology Commission and Chongqing Public Health Commission (2022MSXM050) , and the Senior Medical Talents Program of Chongqing for Young and Middle- aged from Chongqing Health Commission (Receptor: Zhigang Chu) ."