α-Lipoic acid chemistry: the past 70 years

作者全名："Wang, Jia-Qi; Ling, Xu; Wang, Hui-Jing; Chen, Fen-Er"

作者地址："[Wang, Jia-Qi; Chen, Fen-Er] Fudan Univ, Engn Ctr Catalysis & Synth Chiral Mol, Dept Chem, Shanghai 200433, Peoples R China; [Ling, Xu] Chongqing Med Univ, Inst Life Sci, Ctr Novel Target & Therapeut Intervent, Chongqing 400016, Peoples R China; [Wang, Hui-Jing; Chen, Fen-Er] Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Chengdu 610041, Peoples R China"

通信作者："Chen, FE (通讯作者)，Fudan Univ, Engn Ctr Catalysis & Synth Chiral Mol, Dept Chem, Shanghai 200433, Peoples R China.; Wang, HJ; Chen, FE (通讯作者)，Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Chengdu 610041, Peoples R China."

来源：RSC ADVANCES

ESI学科分类：CHEMISTRY

WOS号：WOS:001125298100001

JCR分区：Q2

影响因子：3.9

年份：2023

卷号：13

期号：51

开始页：36346

结束页：36363

文献类型：Review

关键词：　

摘要："alpha-Lipoic acid (ALA) is a naturally occurring sulfur-containing fatty acid with high antioxidant activity. It is also used to treat diabetes, nerve pain, weight loss, heart disease, and primary mitochondrial disorders. Moreover, numerous therapeutic agents have been studied for managing other clinical conditions, including for anticancer, anti-HIV, anti-inflammatory, and anti-AD treatments. The medicinal importance of ALA, especially its biologically active form (R-ALA), has attracted considerable attention from synthetic chemists in industrial and academic fields. In this review, we discuss synthetic approaches to ALA and R-ALA over the past 70 years (1952 to the present), which will help medicinal chemists further develop novel routes for their synthesis. alpha-Lipoic acid (ALA) is a naturally occurring sulfur-containing fatty acid with high antioxidant activity."

基金机构：National Natural Science Foundation of China [2022NSFSC0615]; Sichuan Science and Technology Program [22201192]; National Natural Science Foundation of China

基金资助正文："The authors are grateful for the financial support from Sichuan Science and Technology Program (2022NSFSC0615), National Natural Science Foundation of China (22201192)."