Classification of regulatory T cells and their role in myocardial ischemia-reperfusion injury
作者全名："Li, Junlin; Gong, Yajun; Wang, Yiren; Huang, Huihui; Du, Huan; Cheng, Lianying; Ma, Cui; Cai, Yongxiang; Han, Hukui; Tao, Jianhong; Li, Gang; Cheng, Panke"
作者地址："[Li, Junlin; Gong, Yajun; Wang, Yiren; Huang, Huihui; Du, Huan; Cai, Yongxiang; Han, Hukui; Tao, Jianhong; Li, Gang; Cheng, Panke] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Inst Cardiovasc Dis, Sch Med, Chengdu 610072, Peoples R China; [Li, Junlin; Gong, Yajun; Wang, Yiren; Huang, Huihui; Du, Huan; Cai, Yongxiang; Han, Hukui; Tao, Jianhong; Li, Gang; Cheng, Panke] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sch Med, Dept Cardiol, Chengdu 610072, Peoples R China; [Li, Junlin] Second Peoples Hosp Neijiang, Dept Cardiol, Neijiang 641100, Peoples R China; [Cheng, Lianying] Chongqing Med Univ, Affiliated Hosp 1, Dept Integrated Tradit Chinese & Western Med, Chongqing 400016, Peoples R China; [Ma, Cui] Army Med Univ, Dept Math, Chongqing 400038, Peoples R China; [Cheng, Panke] Ultrasound Cardiac Electrophysiol & Biomech Key La, Chengdu 610072, Peoples R China"
通信作者："Cheng, PK (通讯作者)，Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Inst Cardiovasc Dis, Sch Med, Chengdu 610072, Peoples R China.; Cheng, PK (通讯作者)，Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sch Med, Dept Cardiol, Chengdu 610072, Peoples R China."
来源：JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
ESI学科分类：MOLECULAR BIOLOGY & GENETICS
WOS号：WOS:001125392300001
JCR分区：Q1
影响因子：5
年份：2024
卷号：186
期号：
开始页：94
结束页：106
文献类型：Article
关键词：Myocardial ischemia-reperfusion injury; Regulatory T cells; Immune inflammatory response; Microenvironment; Myocardial infarction
摘要："Myocardial ischemia-reperfusion injury (MIRI) is closely related to the final infarct size in acute myocardial infarction (AMI). Therefore, reducing MIRI can effectively improve the prognosis of AMI patients. At the same time, the healing process after AMI is closely related to the local inflammatory microenvironment. Regulatory T cells (Tregs) can regulate various physiological and pathological immune inflammatory responses and play an important role in regulating the immune inflammatory response after AMI. However, different subtypes of Tregs have different effects on MIRI, and the same subtype of Tregs may also have different effects at different stages of MIRI. This article systematically reviews the classification and function of Tregs, as well as the role of various subtypes of Tregs in MIRI. A comprehensive understanding of the role of each subtype of Tregs can help design effective methods to control immune reactions, reduce MIRI, and provide new potential therapeutic options for AMI."
基金机构："National Natural Science Foundation of China [32000967, 82000530]; Sichuan Provincial People's Hospital Foundation [2020QN01]; Sichuan Cadre Health Research Project [ZH2022-201]; Chengdu Key R & D Support Program Major Technology Application Demonstration Project [2021-YF09-00033-SN]; Natural Science Foundation of Sichuan Province [2022NSFSC0817, 2022NSFSC0811, 23NSFSC1540, 23NSFSC1541]; Sichuan Provincial Science and Technology Program [2023YFS0036]"
基金资助正文："This work was supported by National Natural Science Foundation of China (No. 32000967; No. 82000530) , Sichuan Provincial People's Hospital Foundation (No. 2020QN01) , Sichuan Cadre Health Research Project (No. Chuanganyan ZH2022-201) , Chengdu Key R & D Support Program Major Technology Application Demonstration Project (No. 2021-YF09-00033-SN) , Natural Science Foundation of Sichuan Province (No. 2022NSFSC0817; No. 2022NSFSC0811; No. 23NSFSC1540; No. 23NSFSC1541) and Sichuan Provincial Science and Technology Program (No. 2023YFS0036) ."
