PD-L1-related lncRNAs are associated with malignant characteristics and immune microenvironment in glioma

作者全名："Xia, Zhiwei; Tu, Ruxin; Liu, Fangkun; Zhang, Hao; Dai, Ziyu; Wang, Zeyu; Luo, Peng; He, Shiqing; Xiao, Gelei; Feng, Jie; Cheng, Quan"

作者地址："[Xia, Zhiwei] Hunan Aerosp Hosp, Dept Neurol, Changsha 410205, Hunan, Peoples R China; [Tu, Ruxin; Feng, Jie] Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Hunan, Peoples R China; [Liu, Fangkun; Zhang, Hao; Dai, Ziyu; Wang, Zeyu; Xiao, Gelei; Cheng, Quan] Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Hunan, Peoples R China; [Tu, Ruxin; Feng, Jie; Cheng, Quan] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Hunan, Peoples R China; [Zhang, Hao] Chongqing Med Univ, Affiliated Hosp 2, Dept Neurosurg, Chongqing 400010, Peoples R China; [Wang, Zeyu] Univ Edinburgh, Inst Regenerat & Repair, MRC Ctr Regenerat Med, Little France, Edinburgh EH16 4UU, Midlothian, Scotland; [Luo, Peng] Southern Med Univ, Zhujiang Hosp, Dept Oncol, Guangzhou 510280, Peoples R China; [He, Shiqing] Univ South China, Hengyang Med Coll, Affiliated Nanhua Hosp, Dept Neurosurg, Hengyang 421001, Hunan, Peoples R China; [Feng, Jie] Hunan Clin Res Ctr Cerebrovasc Dis, Changsha 410008, Hunan, Peoples R China"

通信作者："Feng, J (通讯作者)，Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Hunan, Peoples R China.; Cheng, Q (通讯作者)，Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Hunan, Peoples R China.; Feng, J; Cheng, Q (通讯作者)，Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Hunan, Peoples R China.; Feng, J (通讯作者)，Hunan Clin Res Ctr Cerebrovasc Dis, Changsha 410008, Hunan, Peoples R China."

来源：AGING-US

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001125913100044

JCR分区：Q2

影响因子：3.9

年份：2023

卷号：15

期号：19

开始页：10785

结束页：10810

文献类型：Article

关键词：glioma; PD-L1; LINC01271; risk score; prognosis

摘要："Background: The expression of long non-coding RNA (lncRNA) can function as diagnostic and therapeutic biomarker for tumors. This research explores the role of PD-L1-related lncRNAs in affecting malignant characteristics and the immune microenvironment of glioma. Methods: Downloading gene expression profiles and clinicopathological information of glioma from TCGA and CGGA databases, 6 PD-L1-related lncRNAs were identified through correlation analysis, Cox and LASSO regression analysis, establishing the risk score model based on them. Bioinformatics analysis and cell experiments in vitro were adopted to verify the effects of LINC01271 on glioma. Results: Risk scores based on 6 PD-L1-related lncRNAs (AL355974.3, LINC01271, AC011899.3, MIR4500HG, LINC02594, AL357055.3) can reflect malignant characteristics and immunotherapy response of glioma. Patients with high LINC01271 expression had a worse prognosis, a higher abundance of M1 subtype macrophages in the immune microenvironment, and a higher degree of tumor malignancy. Experiments in vitro confirmed its positive regulatory effect on the proliferation and migration of glioma cells. Conclusions: The risk score model based on 6 PD-L1-related lncRNAs can reflect the malignant characteristics and prognosis of glioma. LINC01271 can independently be used as a new target for prognosis evaluation and therapy."

基金机构："National Natural Science Foundation of China Youth Project [82001392, 2022YK04]; Hunan Provincial Natural Science Foundation of China [2022JJ30544]; Fundamental and Applied Research Project of Hengyang Science and Technology Bureau [202250045302]"

基金资助正文："This work was supported by the National Natural Science Foundation of China Youth Project (No. 82001392) , the Science Foundation of AMHT Group (NO.2022YK04) , the Hunan Provincial Natural Science Foundation of China (NO.2022JJ30544) and the Fundamental and Applied Research Project of Hengyang Science and Technology Bureau (202250045302) ."