Prognostic analysis of surgical treatment for T3 glottic laryngeal cancer based on different tumor extension patterns

作者全名："Ling, Zhiming; Hu, Guohua; Wang, Zhihai; Ma, Wei; Wang, Xiaoqiang; Zhu, Jiang; Zeng, Quan"

作者地址："[Ling, Zhiming; Hu, Guohua; Wang, Zhihai; Ma, Wei; Wang, Xiaoqiang; Zhu, Jiang; Zeng, Quan] Chongqing Med Univ, Affiliated Hosp 1, Dept Otolaryngol, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Zeng, Q (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Otolaryngol, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001126697200002

JCR分区：Q2

影响因子：1.9

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Laryngeal neoplasms; Neoplasm invasion; Laryngectomy; Prognosis

摘要："Background and objectives To investigate the prognostic impact of different tumor invasion patterns in the surgical treatment of T3 glottic laryngeal cancer.Methods We conducted a retrospective analysis of clinical data of 91 patients with T3 glottic laryngeal cancer.Results We found that the posterior invasion being significantly associated with involvement of the lamina of cricoid cartilage (P < 0.001), arytenoid cartilage (P = 0.001), and subglottic (P = 0.001). There was no statistical difference in survival outcomes between the total laryngectomy (TL) group and the partial laryngectomy (PL) group, but in the PL group, tumors with anterior invasion were associated with a better 5-year DFS than tumors with posterior invasion (HR: 4.681, 95% CI: 1.337-16.393, P = 0.016), and subglottic involvement was associated with worse LRRFS (HR: 3.931, 95% CI: 1.054-14.658, P = 0.041). At the same time, we found that involvement of the lamina of cricoid cartilage was an independent risk factor for postoperative laryngeal stenosis in PL patients (HR: 11.67, 95% CI: 1.89-71.98, P = 0.008).Conclusion Selectively performed PL can also achieve favorable oncological outcomes comparable to those of TL. Posterior invasion and subglottic involvement are independent prognostic factors for recurrence after PL in T3 glottic laryngeal cancer, and involvement of the lamina of cricoid cartilage is associated with postoperative laryngeal stenosis. The tumor invasion pattern of patients with laryngeal cancer should be further subdivided to allow for selection of a more individualized treatment plan."

基金机构：Science-Health Joint Medical Scientific Research Project of Chongqing [2021MSXM053]; Science and Health Joint Medical Research Program of Chongqing

基金资助正文：This study was supported by of the Science and Health Joint Medical Research Program of Chongqing (Project Number: 2021MSXM053).