Metronidazole-loaded polydopamine nanomedicine with antioxidant and antibacterial bioactivity for periodontitis

作者全名："Yan, Meng; Liang, Wen; Du, Lan; Guo, Rongjuan; Cao, Yu; Ni, Sheng; Zhong, Yuan; Zhang, Kun; Qu, Kai; Qin, Xian; Chen, Liang; Wu, Wei"

作者地址："[Yan, Meng; Cao, Yu; Ni, Sheng; Zhong, Yuan; Zhang, Kun; Qu, Kai; Qin, Xian; Wu, Wei] Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants, Minist Educ,Bioengn Coll, Chongqing 400044, Peoples R China; [Liang, Wen; Du, Lan; Guo, Rongjuan; Chen, Liang] Chongqing Med Univ, Stomatol Hosp, Chongqing 401147, Peoples R China; [Zhang, Kun; Qu, Kai; Qin, Xian] Chongqing Univ Three Gorges Hosp, Chongqing Municipal Clin Res Ctr Geriatr Dis, Chongqing 404000, Peoples R China"

通信作者："Wu, W (通讯作者)，Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants, Minist Educ,Bioengn Coll, Chongqing 400044, Peoples R China.; Chen, L (通讯作者)，Chongqing Med Univ, Stomatol Hosp, Chongqing 401147, Peoples R China."

来源：NANOMEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001128346300001

JCR分区：Q1

影响因子：4.7

年份：2023

卷号：18

期号：29

开始页：2143

结束页：2157

文献类型：Article; Early Access

关键词：antibacterial; antioxidant; nanomedicine; periodontitis; polydopamine

摘要："Aim: This study focused on treating periodontitis with bacterial infection and local over accumulation of reactive oxygen species. Materials & methods: Polydopamine nanoparticles (PDA NPs) were exploited as efficient carriers for encapsulated metronidazole (MNZ). The therapeutic efficacy and biocompatibility of PDA@MNZ NPs were investigated through both in vitro and in vivo studies. Results: The nanodrug PDA@MNZ NPs were successfully fabricated, with well-defined physicochemical characteristics. In vitro, the PDA@MNZ NPs effectively eliminated intracellular reactive oxygen species and inhibited the growth of Porphyromonas gingivalis. Moreover, the PDA@MNZ NPs exhibited synergistic therapy for periodontitisin in vivo. Conclusion: PDA@MNZ NPs were confirmed with exceptional antimicrobial and antioxidant functions, offering a promising avenue for synergistic therapy in periodontitis. A nanotherapeutic composed of dopamine nanoparticles loaded with metronidazole exhibited antimicrobial and antioxidative activities, presenting a safe and effective approach to periodontitis."

基金机构："National Natural Science Foundation of China [31971301, 32171324]; Fundamental Research Funds for the National Key RD Project [2022YFF0710700]; China Postdoctoral Science Foundation [2020M683271, 2022M720574]; Natural Science Foundation of Chongqing [cstc2021jcyj-msxmX0149, CSTB2022NSCQ-BHX0724, CSTB2022NSCQ-BHX0718]; Fundamental Research Funds for Central Universities [2020CDJQY-A061, 2018CDHB1B08]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (31971301,32171324), Fundamental Research Fundsfor the National Key R&D Project (2022YFF0710700), China Postdoctoral Science Foundation (2020M683271, 2022M720574), Natural Science Foundation of Chongqing (cstc2021jcyj-msxmX0149, CSTB2022NSCQ-BHX0724, CSTB2022NSCQ-BHX0718), Fundamental Research Funds for Central Universities (2020CDJQY-A061, 2018CDHB1B08). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed."