Micronanoparticled risedronate exhibits potent vaccine adjuvant effects

作者全名："Nie, Meifeng; Wu, Shuyu; Chen, Yiyi; Wu, Yangtao; Chen, Ruitong; Liu, Yue; Yue, Mingxi; Jiang, Yao; Qiu, Dekui; Yang, Man; Wang, Zikang; Gao, Jiahua; Xiong, Hualong; Qi, Ruoyao; He, Jinhang; Zhang, Jinlei; Wang, Yingbin; Fang, Mujin; Que, Yuqiong; Yao, Youliang; Li, Shaowei; Zhang, Jun; Zhao, Qinjian; Yuan, Quan; Zhang, Tianying; Xia, Ningshao"

作者地址："[Nie, Meifeng; Wu, Shuyu; Chen, Yiyi; Wu, Yangtao; Chen, Ruitong; Liu, Yue; Yue, Mingxi; Jiang, Yao; Qiu, Dekui; Yang, Man; Wang, Zikang; Gao, Jiahua; Xiong, Hualong; Qi, Ruoyao; He, Jinhang; Zhang, Jinlei; Wang, Yingbin; Fang, Mujin; Que, Yuqiong; Yao, Youliang; Li, Shaowei; Zhang, Jun; Yuan, Quan; Zhang, Tianying; Xia, Ningshao] Xiamen Univ, Sch Publ Hlth, State Key Lab Vaccines Infect Dis, Xiang An Biomed Lab, Xiamen 361102, Fujian, Peoples R China; [Nie, Meifeng; Wu, Shuyu; Chen, Yiyi; Wu, Yangtao; Chen, Ruitong; Liu, Yue; Yue, Mingxi; Jiang, Yao; Qiu, Dekui; Yang, Man; Wang, Zikang; Gao, Jiahua; Xiong, Hualong; Qi, Ruoyao; He, Jinhang; Zhang, Jinlei; Wang, Yingbin; Fang, Mujin; Que, Yuqiong; Yao, Youliang; Li, Shaowei; Zhang, Jun; Yuan, Quan; Zhang, Tianying; Xia, Ningshao] Xiamen Univ, Sch Life Sci, Xiamen 361102, Fujian, Peoples R China; [Nie, Meifeng; Wu, Shuyu; Chen, Yiyi; Wu, Yangtao; Chen, Ruitong; Liu, Yue; Yue, Mingxi; Jiang, Yao; Qiu, Dekui; Yang, Man; Wang, Zikang; Gao, Jiahua; Xiong, Hualong; Qi, Ruoyao; He, Jinhang; Zhang, Jinlei; Wang, Yingbin; Fang, Mujin; Que, Yuqiong; Yao, Youliang; Li, Shaowei; Zhang, Jun; Yuan, Quan; Zhang, Tianying; Xia, Ningshao] Xiamen Univ, State Key Lab Mol Vaccinol & Mol Diagnost, Natl Inst Diagnost & Vaccine Dev Infect Dis,NMPA K, Natl Innovat Platform Ind Educ Integrat Vaccine Re, Xiamen 361102, Fujian, Peoples R China; [Zhao, Qinjian] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China"

通信作者："Li, SW; Zhang, J; Yuan, Q; Zhang, TY; Xia, NS (通讯作者)，Xiamen Univ, Sch Publ Hlth, State Key Lab Vaccines Infect Dis, Xiang An Biomed Lab, Xiamen 361102, Fujian, Peoples R China.; Li, SW; Zhang, J; Yuan, Q; Zhang, TY; Xia, NS (通讯作者)，Xiamen Univ, Sch Life Sci, Xiamen 361102, Fujian, Peoples R China.; Li, SW; Zhang, J; Yuan, Q; Zhang, TY; Xia, NS (通讯作者)，Xiamen Univ, State Key Lab Mol Vaccinol & Mol Diagnost, Natl Inst Diagnost & Vaccine Dev Infect Dis,NMPA K, Natl Innovat Platform Ind Educ Integrat Vaccine Re, Xiamen 361102, Fujian, Peoples R China.; Zhao, QJ (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China."

来源：JOURNAL OF CONTROLLED RELEASE

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001128457100001

JCR分区：Q1

影响因子：10.8

年份：2024

卷号：365

期号：　

开始页：369

结束页：383

文献类型：Article

关键词：Risedronate; Particulate adjuvant; Mechanism; Respiratory disease; Elderly population

摘要："Micro/Nano-scale particles are widely used as vaccine adjuvants to enhance immune response and improve antigen stability. While aluminum salt is one of the most common adjuvants approved for human use, its immunostimulatory capacity is suboptimal. In this study, we modified risedronate, an immunostimulant and anti-osteoporotic drug, to create zinc salt particle-based risedronate (Zn-RS), also termed particulate risedronate. Compared to soluble risedronate, micronanoparticled Zn-RS adjuvant demonstrated increased recruitment of innate cells, enhanced antigen uptake locally, and a similar antigen depot effect as aluminum salt. Furthermore, Zn-RS adjuvant directly and quickly stimulated immune cells, accelerated the formulation of germinal centers in lymph nodes, and facilitated the rapid production of antibodies. Importantly, Zn-RS adjuvant exhibited superior performance in both young and aged mice, effectively protecting against respiratory diseases such as SARS-CoV-2 challenge. Consequently, particulate risedronate showed great potential as an immune-enhancing vaccine adjuvant, particularly beneficial for vaccines targeting the susceptible elderly."

基金机构："National Key Research and Development Program of China [82322027, 81991495, U1905205, 32070925, 2022YFC0870800, 20720220003]; Fundamental Research Funds for the Central Universities; [32170943]; [82341043]"

基金资助正文："This study was funded by National Natural Science Foundation of China grants 32170943 (to T.Y.Z.) , 82341043 (to T.Y.Z.) , 82322027 (to T.Y.Z.) , 81991495 (to T.Y.Z.) , U1905205 (to Q.Y.) , 32070925 (to Q.J. Z.) , National Key Research and Development Program of China 2022YFC0870800 (to N.S.X.) , and the Fundamental Research Funds for the Central Universities (20720220003) ."