Mutual communication between radiosensitive and radioresistant esophageal cancer cells modulates their radiosensitivity

作者全名："Xie, Congying; Chen, Xiao; Chen, Yueming; Wang, Xingyue; Zuo, Jiwei; Zheng, Anqi; Luo, Zhicheng; Cheng, Xiaoxiao; Zhong, Shouhui; Jiang, Jiayu; Du, Jizao; Zhao, Yuemei; Jiang, Peipei; Zhang, Wei; Chen, Didi; Pan, Huanle; Shen, Lanxiao; Zhu, Baoling; Zhou, Qingyu; Xu, Yunsheng; Tang, Kai-Fu"

作者地址："[Xie, Congying; Zhu, Baoling; Zhou, Qingyu; Tang, Kai-Fu] Wenzhou Med Univ, Zhejiang Engn Res Ctr Innovat & Applicat Intellige, Affiliated Hosp 2, Wenzhou 325000, Zhejiang, Peoples R China; [Xie, Congying; Zhu, Baoling; Zhou, Qingyu] Wenzhou key Lab Basic Sci & Translat Res Radiat On, Wenzhou 325000, Zhejiang, Peoples R China; [Chen, Xiao] Zhejiang Univ, Affiliated Hosp 2, Key Lab Precis Diag & Treatment Hepatobiliary & Pa, Sch Med, Hangzhou 310009, Zhejiang, Peoples R China; [Chen, Xiao; Chen, Yueming; Wang, Xingyue; Zuo, Jiwei; Zheng, Anqi; Luo, Zhicheng; Cheng, Xiaoxiao; Zhong, Shouhui; Jiang, Jiayu; Du, Jizao; Zhao, Yuemei] Wenzhou Med Univ, Key Lab Diag & Treatment Severe Hepatopancreat Dis, Affiliated Hosp 1, Wenzhou 325015, Zhejiang, Peoples R China; [Jiang, Peipei; Zhang, Wei] Wenzhou Med Univ, Dept Breast Surg, Affiliated Hosp 1, Wenzhou 325015, Zhejiang, Peoples R China; [Chen, Didi] Wenzhou Med Univ, Dept Radiat Oncol, Affiliated Hosp 1, Wenzhou 325015, Zhejiang, Peoples R China; [Pan, Huanle; Shen, Lanxiao] Wenzhou Med Univ, Dept Radiotherapy Ctr, Affiliated Hosp 1, Wenzhou 325015, Zhejiang, Peoples R China; [Xu, Yunsheng] Sun Yat Sen Univ, Affiliated Hosp 7, Dept Dermatovenereol, Shenzhen 518107, Peoples R China; [Tang, Kai-Fu] Chongqing Med Univ, Key Lab Mol Biol Infect Dis, Minist Educ, Chongqing 400016, Peoples R China"

通信作者："Tang, KF (通讯作者)，Wenzhou Med Univ, Zhejiang Engn Res Ctr Innovat & Applicat Intellige, Affiliated Hosp 2, Wenzhou 325000, Zhejiang, Peoples R China.; Tang, KF (通讯作者)，Chongqing Med Univ, Key Lab Mol Biol Infect Dis, Minist Educ, Chongqing 400016, Peoples R China."

来源：CELL DEATH & DISEASE

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001128517700001

JCR分区：Q1

影响因子：8.1

年份：2023

卷号：14

期号：12

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Radiotherapy is an important treatment modality for patients with esophageal cancer; however, the response to radiation varies among different tumor subpopulations due to tumor heterogeneity. Cancer cells that survive radiotherapy (i.e., radioresistant) may proliferate, ultimately resulting in cancer relapse. However, the interaction between radiosensitive and radioresistant cancer cells remains to be elucidated. In this study, we found that the mutual communication between radiosensitive and radioresistant esophageal cancer cells modulated their radiosensitivity. Radiosensitive cells secreted more exosomal let-7a and less interleukin-6 (IL-6) than radioresistant cells. Exosomal let-7a secreted by radiosensitive cells increased the radiosensitivity of radioresistant cells, whereas IL-6 secreted by radioresistant cells decreased the radiosensitivity of radiosensitive cells. Although the serum levels of let-7a and IL-6 before radiotherapy did not vary significantly between patients with radioresistant and radiosensitive diseases, radiotherapy induced a more pronounced decrease in serum let-7a levels and a greater increase in serum IL-6 levels in patients with radioresistant cancer compared to those with radiosensitive cancer. The percentage decrease in serum let-7a and the percentage increase in serum IL-6 levels at the early stage of radiotherapy were inversely associated with tumor regression after radiotherapy. Our findings suggest that early changes in serum let-7a and IL-6 levels may be used as a biomarker to predict the response to radiotherapy in patients with esophageal cancer and provide new insights into subsequent treatments."

基金机构："National Natural Science Foundation of China (National Science Foundation of China) [81972648, 82172915, 81773011, 82273570]; National Natural Science Foundation of China [Y20180080]; Wenzhou Municipal Science and Technology Bureau [W0084]; Chongqing Medical University Program for Youth Innovation in Future Medicine"

基金资助正文："The authors wish to thank Dr. Yi Jin (The First Affiliated Hospital of Wenzhou Medical University) for her assistance with the pathology techniques and Prof. Fengming Kong (The University of Hong Kong) for her critical reading of the manuscript. This work was supported by the National Natural Science Foundation of China (grant numbers 81972648, 82172915, 81773011, and 82273570), the Wenzhou Municipal Science and Technology Bureau (grant number Y20180080), and the Chongqing Medical University Program for Youth Innovation in Future Medicine (grant number W0084)."