Mesenchymal stem cells-based drug delivery systems for diabetic foot ulcer: A review

作者全名："Zhang, Hong-Min; Yang, Meng-Liu; Xi, Jia-Zhuang; Yang, Gang-Yi; Wu, Qi-Nan"

作者地址："[Zhang, Hong-Min] Peoples Hosp Chongqing Liangjiang New Area, Dept Endocrinol, Chongqing 400030, Peoples R China; [Yang, Meng-Liu; Yang, Gang-Yi] Chongqing Med Univ, Dept Endocrinol, Affiliated Hosp 2, Chongqing 400030, Peoples R China; [Xi, Jia-Zhuang; Wu, Qi-Nan] Chongqing Med Univ, Peoples Hosp Dazu, Dept Endocrinol, Dazu Hosp, Chongqing 406230, Peoples R China; [Wu, Qi-Nan] Chongqing Med Univ, Peoples Hosp Dazu, Dept Endocrinol, Dazu Hosp, 1073 Second Ring South Rd,Tangxiang St, Chongqing 406230, Peoples R China"

通信作者："Wu, QN (通讯作者)，Chongqing Med Univ, Peoples Hosp Dazu, Dept Endocrinol, Dazu Hosp, 1073 Second Ring South Rd,Tangxiang St, Chongqing 406230, Peoples R China."

来源：WORLD JOURNAL OF DIABETES

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001130387900008

JCR分区：Q1

影响因子：4.2

年份：2023

卷号：14

期号：11

开始页：1585

结束页：1602

文献类型：Review

关键词：Diabetic foot ulcer; Mesenchymal stem cells; Drug delivery systems; Diabetes; Wound healing

摘要："The complication of diabetes, which is known as diabetic foot ulcer (DFU), is a significant concern due to its association with high rates of disability and mortality. It not only severely affects patients' quality of life, but also imposes a substantial burden on the healthcare system. In spite of efforts made in clinical practice, treating DFU remains a challenging task. While mesenchymal stem cell (MSC) therapy has been extensively studied in treating DFU, the current efficacy of DFU healing using this method is still inadequate. However, in recent years, several MSCs-based drug delivery systems have emerged, which have shown to increase the efficacy of MSC therapy, especially in treating DFU. This review summarized the application of diverse MSCs-based drug delivery systems in treating DFU and suggested potential prospects for the future research."

基金机构："Science and Health Joint Medical Research Project of Chongqing [2022MSXM133]; Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX1522, CSTB2023NSCQ-MSX0246, CSTB2022NSCQ-MSX1271]; First Batch of Key Disciplines on Public Health in Chongqing and Science; Health Joint Project of Dazu District Science and Technology Bureau [DZKJ,2022CCC1001]"

基金资助正文："Supported by Science and Health Joint Medical Research Project of Chongqing, No. 2022MSXM133; Natural Science Foundation of Chongqing, No. CSTB2022NSCQ-MSX1522, No. CSTB2023NSCQ-MSX0246, and No. CSTB2022NSCQ-MSX1271; The First Batch of Key Disciplines on Public Health in Chongqing and Science; and Health Joint Project of Dazu District Science and Technology Bureau, No. DZKJ,2022CCC1001."