Primary pulmonary adenoid cystic carcinoma: A clinicopathological study of 64 patients

作者全名："Tan, Xiang; Xu, Tao; Shen, Wang; Ai, Cheng; Zhang, Weilin; Tang, Xiaojun; Luo, Feng; Zhou, Qinghua"

作者地址："[Tan, Xiang; Luo, Feng] Sichuan Univ, West China Hosp, Canc Ctr, Dept Med Oncol, Chengdu, Peoples R China; [Tan, Xiang; Shen, Wang; Tang, Xiaojun; Luo, Feng; Zhou, Qinghua] Sichuan Univ, West China Hosp, Lung Canc Ctr, Chengdu, Peoples R China; [Tan, Xiang] Guangxi Med Univ, Dept Thorac Surg, Affiliated Hosp 1, Nanning, Peoples R China; [Xu, Tao] Southwest Med Univ, Dept Thorac Surg, Affiliated Hosp, Luzhou, Peoples R China; [Shen, Wang; Zhang, Weilin; Tang, Xiaojun; Zhou, Qinghua] Sichuan Univ, West China Tianfu Hosp, Lung Canc Ctr, Chengdu, Peoples R China; [Ai, Cheng] Chongqing Med Univ, Bishan Hosp, Dept Cardiothorac Surg, Chongqing, Peoples R China; [Zhang, Weilin] Sichuan Univ, West China Hosp, Rehabil Med Ctr, Chengdu, Peoples R China; [Luo, Feng; Zhou, Qinghua] Sichuan Univ, West China Hosp, Lung Canc Ctr, Chengdu 610041, Peoples R China"

通信作者："Zhou, QH (通讯作者)，Sichuan Univ, West China Tianfu Hosp, Lung Canc Ctr, Chengdu, Peoples R China.; Luo, F; Zhou, QH (通讯作者)，Sichuan Univ, West China Hosp, Lung Canc Ctr, Chengdu 610041, Peoples R China."

来源：THORACIC CANCER

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001130391900001

JCR分区：Q2

影响因子：2.3

年份：2024

卷号：15

期号：5

开始页：386

结束页：393

文献类型：Article; Early Access

关键词：lung cancer; pathology; primary pulmonary adenoid cystic carcinoma

摘要："BackgroundThis study aimed to investigate the clinicopathological features and prognostic indicators of primary pulmonary adenoid cystic carcinoma (PACC).MethodsClinical data were collected from 64 primary PACC patients and analyzed retrospectively at the Tianjin Medical University General Hospital, the West China Hospital of Sichuan University, the First Affiliated Hospital of Guangxi Medical University, and the Bishan Hospital of Chongqing Medical University from January 2003 to August 2023. The 64 patients (28 males and 36 females) were aged from 20 to 73 years, with a median age of 49 years and an average age of 49.3 years.ResultsImmunohistochemical staining showed that the tumors expressed CK7, S-100 protein, CK5/6, CD117, and p63. Seven patients underwent fluorescence in situ hybridization (FISH) testing and three were found to have myeloblastosis (MYB) gene translocation. In total, 53 patients underwent surgery, among whom 31 received only surgery and 22 received both surgery and postoperative chemoradiotherapy. In addition, 10 patients received chemoradiotherapy only, while one patient underwent treatment with traditional Chinese medicine. The overall survival rates in the first, third, and fifth years were 98.4%, 95.3%, and 87.5%, respectively.ConclusionPrognostic analysis revealed that age, tumor size, lymph node metastasis status, margin status, and choice of treatment modality significantly influenced the patients' prognosis. The pathological characteristic of primary pulmonary adenoid cystic carcinoma.image"

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