Prognostic Factors in Pediatric Alveolar Rhabdomyosarcoma: SEER Analysis of 277 Cases

作者全名："Zhang, Li; He, Jiali; Yu, Xianhai; Zhang, Deying"

作者地址："[Zhang, Li; He, Jiali; Yu, Xianhai; Zhang, Deying] Childrens Hosp Chongqing Med Univ, Chongqing, Peoples R China; [Zhang, Deying] Natl Clin Res Ctr Child Hlth & Disorders, Chongqing, Peoples R China; [Zhang, Deying] Childrens Hosp Chongqing Med Univ, Dept Urol, Chongqing 400014, Peoples R China"

通信作者："Zhang, DY (通讯作者)，Childrens Hosp Chongqing Med Univ, Dept Urol, Chongqing 400014, Peoples R China."

来源：CLINICAL PEDIATRICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001133425900001

JCR分区：Q3

影响因子：1

年份：2023

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期号：　

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文献类型：Article; Early Access

关键词：alveolar rhabdomyosarcoma; childhood cancer; cancer survival

摘要："Alveolar rhabdomyosarcoma (ARMS) is a rare but highly aggressive cancer predominantly affecting children and adolescents. This study explores prognostic factors for pediatric and adolescent ARMS, using the Surveillance, Epidemiology, and End Results (SEER) database. Leveraging SEER data (2000-2019), we analyzed 277 cases. Employing Kaplan-Meier survival analysis and Cox proportional hazards models, we identified significant prognostic factors. Gender distribution was nearly equal (56.0% boys, 44.0% girls), with the majority (70.8%) from the white ethnic group. Primary tumors were predominantly in extremities (37.2%). Distant metastases significantly increased mortality risk (hazard ratio [HR], 3.13; 95% CI: 2.14-4.58) and regional lymph node involvement raised mortality risk (HR, 1.36; 95% CI: 0.96-1.92). Chemotherapy-only treatment had higher mortality risk than chemoradiotherapy (HR, 1.16; 95% CI: 0.97-2.67). Conclusively, our study identifies distant metastases, regional lymph node involvement, and treatment modality as crucial predictors of overall survival in pediatric ARMS."

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