Positive association between omega-3/6 polyunsaturated fatty acids and idiopathic normal pressure hydrocephalus: a mendelian randomization study

作者全名："Li, Jilai; Huang, Ning; Zhang, Xiang; Peng, Jie; Huang, Qin"

作者地址："[Li, Jilai; Huang, Ning; Zhang, Xiang; Peng, Jie; Huang, Qin] Chongqing Med Univ, Dept Neurosurg, Affiliated Hosp 2, Chongqing, Peoples R China"

通信作者："Huang, Q (通讯作者)，Chongqing Med Univ, Dept Neurosurg, Affiliated Hosp 2, Chongqing, Peoples R China."

来源：FRONTIERS IN GENETICS

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001133999300001

JCR分区：Q2

影响因子：2.8

年份：2023

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：idiopathic normal pressure hydrocephalus; omega-3 fatty acids; omega-6 fatty acids; mendelian randomization; causality

摘要："Background: Idiopathic normal pressure hydrocephalus (iNPH) is a common disease among the elderly, which brings great harm to the health of patients and imposes a huge economic burden on the healthcare system. Research has shown that it is possible to prevent iNPH through nutritional and dietary interventions. Intake of omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) can reduce the risk of many diseases. In this study, we aimed to explore the association between omega-3/6 PUFAs and iNPH.Methods: We conducted a two-sample Mendelian randomization (MR) study using summary data from publicly available genome-wide association studies (GWAS) to evaluate the potential impact of omega-3 and omega-6 PUFAs on the risk of iNPH in European populations. Inverse variance weighting was used as the main method for MR analysis, with Wald ratio, weighted median, MR-Egger, simple mode, and weighted mode as supplementary methods. In addition, we performed a series of instrument variable strength evaluations and sensitivity analyses to test the reliability of the study results. Finally, we also conducted a linkage disequilibrium score regression (LDSC) analysis to assess the genetic correlation and distinguish between causal associations and shared genetic variants between PUFAs and iNPH.Results: One SD increase in genetically predicted levels of total omega-3 PUFAs (OR: 0.748; 95% CI: 0.597-0.937; p = 0.012; IVW), DHA (OR: 0.709; 95% CI: 0.532-0.945; p = 0.019; IVW), ALA (OR: 0.001; 95% CI: 1.17E-06-0.423; p = 0.026; Wald ratio), and DHA (OR: 0.709; 95% CI: 0.532-0.945; p = 0.019; IVW) were associated with a reduced iNPH risk. LDSC did not reveal any significant genetic correlations.Conclusion: Higher genetically predicted levels of total omega-3 PUFAs, ALA, DHA, and DPA are associated with a reduced risk of iNPH. These findings have important implications for preventing iNPH and future nutritional guidance."

基金机构："Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission10.13039/501100012669"

基金资助正文：We thank the authors and researchers of all GWAS from which we used summary statistics datasets. Special thanks to the researchers and administrators of the IEU GWAS database project for making the GWAS data publicly available and to the participants and researchers of the FinnGen study for providing the GWAS dataset for normal pressure hydrocephalus.