Salidroside attenuates myocardial remodeling in DOCA-salt-induced mice by inhibiting the endothelin 1 and PI3K/AKT/NFκB signaling pathways

作者全名："Liu, Qiao; Luo, Qingman; Zhong, Bin; Tang, Kecheng; Chen, Xueling; Yang, Shengqian; Li, Xiaohui"

作者地址："[Liu, Qiao; Luo, Qingman; Zhong, Bin; Tang, Kecheng; Yang, Shengqian; Li, Xiaohui] Army Med Univ, Inst Mat Med, Coll Pharm, Chongqing 400038, Peoples R China; [Liu, Qiao; Luo, Qingman; Zhong, Bin; Tang, Kecheng; Yang, Shengqian; Li, Xiaohui] Army Med Univ, Coll Pharm, Dept Pharmaceut, Gao Tan Yan Str 30, Chongqing 400038, Peoples R China; [Liu, Qiao] Chongqing Med & Pharmaceut Coll, Dept Pharmaceut, Chongqing 401331, Peoples R China; [Chen, Xueling] Chongqing Univ Technol, Chongqing Sch Pharm & Bioengn, Chongqing 400054, Peoples R China; [Yang, Shengqian; Li, Xiaohui] Army Med Univ, Chongqing Engn Res Ctr Pharmacodynam Evaluat, Inst Mat Med, Coll Pharm, Gao Tan Yan St 30, Chongqing 400038, Peoples R China"

通信作者："Yang, SQ; Li, XH (通讯作者)，Army Med Univ, Coll Pharm, Dept Pharmaceut, Gao Tan Yan Str 30, Chongqing 400038, Peoples R China.; Yang, SQ; Li, XH (通讯作者)，Army Med Univ, Chongqing Engn Res Ctr Pharmacodynam Evaluat, Inst Mat Med, Coll Pharm, Gao Tan Yan St 30, Chongqing 400038, Peoples R China."

来源：EUROPEAN JOURNAL OF PHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001135074900001

JCR分区：Q1

影响因子：5

年份：2024

卷号：962

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Salidroside; Myocardial remodeling; Endothelin-1; PI3K/AKT/NF kappa B

摘要："Myocardial remodeling, which occurs in the final stage of cardiovascular diseases such as hypertension, can ultimately result in heart failure. However, the pathogenesis of myocardial remodeling remains incompletely understood, and there is currently a lack of safe and effective treatment options. Salidroside, which is extracted from the plant Rhodiola rosea, shows remarkable antioxidant and anti-inflammatory characteristics. The purpose of this investigation was to examine the cardioprotective effect of salidroside on myocardial remodeling, and clarify the associated mechanism. Salidroside effectively attenuated cardiac dysfunction, myocardial hypertrophy, myocardial fibrosis, and cardiac inflammation, as well as renal injury and renal fibrosis in an animal model of deoxycortone acetate (DOCA)-salt-induced myocardial remodeling. The cardioprotective effect of salidroside was mediated by inhibiting the endothelin 1 and PI3K/AKT/NF kappa B signaling pathways. Salidroside was shown to inhibit the expression of endothelin1 in the hearts of mice treated with DOCA-salt. Additionally, it could prevent cardiomyocyte hypertrophy induced by endothelin-1 stimulation. Furthermore, Salidroside could effectively inhibit the excessive activation of the PI3K/AKT/NF kappa B pathway, which was caused by DOCA-salt treatment in mouse hearts and endothelin 1 stimulation in cardiomyocytes. Our study suggests that salidroside can be used as a therapeutic agent for the treatment of myocardial remodeling."

基金机构：National Natural Scientific Foundation of China [82273921]; Science and Technology Research Program of Chongqing Municipal Education Commission [KJQN202212809]

基金资助正文："This study was supported by grants of National Natural Scientific Foundation of China (No. 82273921) , the Science and Technology Research Program of Chongqing Municipal Education Commission (No. KJQN202212809) ."