Long-term outcome and risk factors of reintervention after high intensity focused ultrasound ablation for uterine fibroids: a systematic review and meta-analysis

作者全名："Dou, Yuya; Zhang, Lian; Liu, Yu; He, Min; Wang, Yanzhou; Wang, Zhibiao"

作者地址："[Dou, Yuya; Zhang, Lian; He, Min; Wang, Zhibiao] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China; [Liu, Yu] Peoples Liberat Army Gen Hosp, Hainan Hosp, Dept Obstet & Gynecol, Sanya, Peoples R China; [Dou, Yuya; Wang, Yanzhou] Army Mil Med Univ, Southwest Hosp, Dept Obstet & Gynecol, Chongqing, Peoples R China; [Wang, Zhibiao] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China"

通信作者："Wang, ZB (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China."

来源：INTERNATIONAL JOURNAL OF HYPERTHERMIA

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001135314400001

JCR分区：Q2

影响因子：3

年份：2024

卷号：41

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：Uterine fibroid; high-intensity focused ultrasound; reintervention rate; meta-analysis

摘要："ObjectivesTo quantify the reintervention rate and analyze the risk factors for reintervention after high-intensity focused ultrasound (HIFU) ablation of uterine fibroids.MethodsEighteen studies were selected from the seven databases. A meta-analysis was applied to synthesize the reintervention rates for fibroids across various follow-up durations. Subgroup-analysis was conducted based on the year of surgery, sample size, guide methods, and non-perfusion volume ratio (NPVR). Signal intensity of T2-weighted imaging (T2WI) was independently evaluated for reintervention risk.ResultsThe study enrolled 5216 patients with fibroids treated with HIFU. There were 3247, 1239, 1762, and 2535 women reaching reintervention rates of 1% (95% confidence interval (CI): 1-1), 7% (95% CI: 4-11), 19% (95% CI: 11-27), and 29% (95% CI: 14-44) at 12, 24, 36, and 60-month after HIFU. The reintervention rates of patients treated with US-guided HIFU (USgHIFU) were significantly lower than those of patients treated with MR-guided focused ultrasound surgery (MRgFUS). When the NPVR of fibroids was over 50%, the reintervention rates at 12, 36 and 60-month after HIFU were 1% (95% CI: 0.3-2), 5% (95% CI: 3-8), and 15% (95% CI: 9-20). The reintervention risk for hyper-intensity fibroids on T2WI was 3.45 times higher (95% CI: 2.7-4.39) for hypo-/iso-intensity fibroids.ConclusionThis meta-analysis showed that the overall reintervention rates after HIFU were acceptable and provided consultative suggestions regarding treatment alternatives for patients with fibroids. Subgroup-analysis revealed that USgHIFU, NPVR >= 50%, and hypo-/iso-intensity of fibroids on T2WI were significant factors in reducing reintervention.Systematic Review RegistrationPROSPERO, CRD42023456094"

基金机构：Foundation of State Key Laboratory of Ultrasound in Medicine and Engineering

基金资助正文：The authors acknowledge all the people who helped us.