Gut microbiota alteration and its association with immune function in post-COVID-19 patients

作者全名："Cai, Jiaojiao; Xu, Jingru; Tan, Yan; Xiang, Yao; Li, Zhifeng; Zheng, Juan; Li, Yingli"

作者地址："[Cai, Jiaojiao; Li, Yingli] Chongqing Med Univ, Coll Publ Hlth, Chongqing 400016, Peoples R China; [Cai, Jiaojiao; Xu, Jingru; Tan, Yan; Xiang, Yao; Li, Zhifeng] Chongqing Ctr Dis Control & Prevent, Microbiol Lab, Chongqing 400042, Peoples R China; [Zheng, Juan] Peoples Hosp Jiangbei Dist, Chongqing Red Cross Hosp, Dept Neurol, Chongqing 400020, Peoples R China"

通信作者："Li, YL (通讯作者)，Chongqing Med Univ, Coll Publ Hlth, Chongqing 400016, Peoples R China."

来源：FOLIA MICROBIOLOGICA

ESI学科分类：MICROBIOLOGY

WOS号：WOS:001136058900001

JCR分区：Q3

影响因子：2.6

年份：2024

卷号：69

期号：4

开始页：857

结束页：864

文献类型：Article

关键词：COVID-19; Gut microbiota; Immune function; Variation; 16S rRNA

摘要："To reveal the variation of gut microbiota and its association with immune function in cured patients with coronavirus 2019 (COVID-19) disease, gut microbiota of patients discharged from hospital for 20 similar to 23 months and healthy volunteers was analyzed by high throughput 16S rRNA sequencing. The diversity and abundance were compared, and the correlation with immunity factors was investigated, and changes in the content of 6 genera microorganisms with proportion higher than 0.1% were revealed in patients with COVID-19 disease: reduced content of Subdoligranulum, Haemophilus, Coprococcus, Eubacterium vertriosum group, and Lachnospiraceae ND3007 group and increased content of Hungatella. NK cells were negatively correlated to Subdoligranulum, while CD8 cells were positively correlated to Subdoligranulum but negative to Hungatella. IL-8 concentration was negatively correlated to Subdoligranulum, Haemophilus, Coprococcus, Eubacterium vertriosum group, and Lachnospiraceae ND3007 group but positively to Hungatella, while IL-1 beta concentration was negatively correlated to Haemophilus and Eubacterium ventriosum group but positively to Hungatella. The variation of probiotics and potential pathogenic bacteria implies a higher risk in diseases and inflammation, and the modulation of the gut microbiota may help the healing of COVID-19 patients."

基金机构：Chongqing Science and Health Joint Medical Research Foundation

基金资助正文：No Statement Available