Herpes Zoster Ophthalmicus Clinical Presentation and Risk Factors for Lesion Recovery
作者全名:"Xiao, Zupeng; Wu, Hanyi; Chen, Xin; Chen, Xiaoli; Yu, Rentao; Chen, Aijun"
作者地址:"[Xiao, Zupeng; Wu, Hanyi; Chen, Xin; Chen, Xiaoli; Yu, Rentao; Chen, Aijun] Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 1, Chongqing, Peoples R China; [Yu, Rentao; Chen, Aijun] Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China"
通信作者:"Yu, RT; Chen, AJ (通讯作者),Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China."
来源:CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
ESI学科分类:
WOS号:WOS:001136699100001
JCR分区:Q3
影响因子:1.9
年份:2023
卷号:16
期号:
开始页:3767
结束页:3773
文献类型:Article
关键词:herpes zoster ophthalmicus; clinical manifestations; disease outcome; risk factors
摘要:"Purpose: Herpes zoster ophthalmicus (HZO) causes trouble in patients' daily life and work. In severe cases, it may even lead to a decrease or loss of vision. To understand the demographic information and ocular symptoms of hospitalized patients with HZO, and to find potential factors related to improvement time of skin rash and duration of ocular symptoms at discharge, we design this study. Patients and methods: This is a retrospective study. All patients diagnosed with HZO who were hospitalized in the Department of Dermatology of a hospital in Chongqing, China from January 1, 2015 to December 30, 2021 were included in this study. A total of 189 patients were included in this study. Clinical manifestations of the disease during hospitalization, improvement time of ocular skin lesions, and whether ocular skin lesions disappeared completely at discharge were recorded. Results: The most common ocular symptom was eyelid swelling (92.6%), followed by eye pain (48.7%). The most common ocular sign was conjunctivitis (78.3%), followed by keratitis (15.9%). There were 149 cases without residual ocular symptoms and 40 cases with residual ocular symptoms. There was no statistically significant difference in demographic characteristics between the two groups (P>0.05). Age >= 70 years (B=0.381, -0.061 similar to 0.022, P=0.005), use of glucocorticoids (B=0.260, 0.024 similar to 0.496, P=0.031), and use of topical antiviral drugs (B=0.380, 0.054 similar to 0.705, P=0.023) were factors affecting the time interval from admission to improvement of skin rash. Tearing (HR, OR=4.827, 1.956 similar to 11.909, P<0.001) and blood urea nitrogen (OR=0.787, 0.620-1.000, P=0.050) were factors influencing residual ocular symptoms. Conclusion: This study could help clinicians gain a deeper understanding of the clinical manifestations and partial influencing factors of HZO patients, which may contribute to future clinical work."
基金机构:Special Foundation for Postdoctoral Research Projects of Chongqing [2021XM3080]; Natural Science Foundation General Program of Chongqing [cstc2021jcyj-msxmX0182]; Natural Science Foundation General Program of China [81874238]
基金资助正文:"<B>Funding</B> This study was supported by Special Foundation for Postdoctoral Research Projects of Chongqing (2021XM3080) , Natural Science Foundation General Program of Chongqing (cstc2021jcyj-msxmX0182) and Natural Science Foundation General Program of China (81874238) ."