Clinical characteristics of three distinct types of pancreatitis with overlapping etiologies: A ten-year retrospective cohort study

作者全名："Zhang, Qiwei; Fu, Zhan; Li, Shengwei; Ding, Xiong; Zhang, Wenfeng; Ma, Rong; Zhai, Qilong"

作者地址："[Zhang, Qiwei; Fu, Zhan] Chongqing Med Univ, Hepatobiliary & Pancreat Surg Dept, Banan Hosp, Chongqing 401320, Peoples R China; [Li, Shengwei; Ding, Xiong; Zhang, Wenfeng; Ma, Rong; Zhai, Qilong] Chongqing Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 2, Chongqing 400010, Peoples R China; [Ma, Rong; Zhai, Qilong] 74 Linjiang Rd, Chongqing 400010, Peoples R China"

通信作者："Ma, R; Zhai, QL (通讯作者)，Chongqing Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 2, Chongqing 400010, Peoples R China.; Ma, R; Zhai, QL (通讯作者)，74 Linjiang Rd, Chongqing 400010, Peoples R China."

来源：PANCREATOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001136853700001

JCR分区：Q2

影响因子：2.8

年份：2023

卷号：23

期号：8

开始页：949

结束页：956

文献类型：Article; Early Access

关键词：Acute pancreatitis; Acute biliary pancreatitis; Biliary-hypertriglyceridemia acute; pancreatitis; Etiology; Hypertriglyceridemia acute pancreatitis

摘要："Background: Hypertriglyceridemia (HTG) is frequently observed in non-HTG-induced acute pancreatitis (AP), such as in the early stage of acute biliary pancreatitis (ABP). There is overlap in the etiologies of ABP, HTG-AP, and biliary-hypertriglyceridemia acute pancreatitis (BHAP), which may be perplexing for clinicians.Methods: We retrospectively analyzed 394 AP patients. The patients were divided into three groups based on etiology. We analyzed the differences among the three groups of patients in terms of general information, laboratory parameters, and prognosis.Results: The mean age of patients in the ABP group was significantly higher than that in the HTG-AP and BHAP groups (p < 0.001). Females made up a greater percentage of the ABP group, whereas males made up the majority in the HTG-AP and BHAP groups. The ABP group had the highest PCT, AMS, LPS, ALT, AST, GGT, TBIL, DBIL, APACHE II, and BISAP scores. TG and BMI were highest in the HTG-AP group. AST and GGT levels were substantially greater in BHAP patients than those in HTG-AP. The BHAP group had the greatest incidence of organ failure, systemic complications, and local complications.Conclusion: ABP usually develops in people aged 50-59 years. HTG-AP primarily affects people aged 30 -39 years. However, the peak incidence age of BHAP falls between the two aforementioned age groups (40-49 years). We also found that patients with BHAP seem to be in an intermediate state in terms of some biochemical markers and demographic characteristics. Furthermore, BHAP may have the worst clinical outcomes compared with HTG-AP and ABP.(c) 2023 The Authors. Published by Elsevier B.V. on behalf of IAP and EPC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)."

基金机构：National Natural Science Foundation of China [82173117]; Kuanren Talents Program of The Second Affiliated Hospital of Chongqing Medical University [kryc-yq-2209]

基金资助正文："<BOLD>Funding</BOLD> The study was funded by National Natural Science Foundation of China (No. 82173117) , and Kuanren Talents Program of The Second Affiliated Hospital of Chongqing Medical University (No. kryc-yq-2209)"