Influence of Fibrinogen/Albumin Ratio and Fibrinogen/Pre-Albumin Ratio on Cardiac Autonomic Neuropathy in Type 2 Diabetes

作者全名："Zhao, Subei; Yang, Zheng; Yu, Meng; Xiang, Linyu; Lv, Yuhuan; Tian, Chunyan; Li, Rong"

作者地址："[Zhao, Subei; Yang, Zheng; Yu, Meng; Xiang, Linyu; Lv, Yuhuan; Tian, Chunyan; Li, Rong] Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrinol, Chongqing 400010, Peoples R China"

通信作者："Li, R (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrinol, Chongqing 400010, Peoples R China."

来源：DIABETES METABOLIC SYNDROME AND OBESITY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001137015100001

JCR分区：Q3

影响因子：2.8

年份：2023

卷号：16

期号：　

开始页：3249

结束页：3259

文献类型：Article

关键词：type 2 diabetes mellitus; diabetic cardiac autonomic neuropathy; inflammation; fibrinogen-albumin ratio; fibrinogen-prealbumin ratio

摘要："Purpose: Subclinical inflammation may be involved in the pathogenesis of diabetic cardiac autonomic neuropathy (DCAN). The purpose of the study is to explore the relationship between novel inflammation biomarkers fibrinogen-albumin ratio (FAR), fibrinogenprealbumin ratio (FPR), and DCAN in type 2 diabetes mellitus (T2DM).Patients and Methods: A total of 715 T2DM patients were enrolled in this retrospective study, divided into non-DCAN (n=565) and DCAN (n=150) groups by Ewing's test. Serum fibrinogen, albumin, prealbumin, routine inflammatory and other biochemical markers were measured.Results: Patients with versus without DCAN had higher FAR (10.29 +/- 4.83 vs 7.22 +/- 2.56 g/g, P < 0.001) and FPR (2.19 +/- 1.85 vs 1.43 +/- 0.93 g/mg, P < 0.001). As FAR and FPR quartiles increased, the incidence of DCAN increased (Quartile 1 vs Quartile 4: 8.4 vs 42.7%, 9.6 vs 39.2%, respectively, P < 0.001), heart rate variability parameters decreased (P < 0.001); the incidence of diabetic nephropathy, retinopathy and peripheral neuropathy tended to be higher and inflammation factors were more active (P < 0.01). FAR (OR, 95% CI: 1.16, 1.08-1.25, P < 0.001) and FPR (OR, 95% CI: 1.22, 1.03-1.44, P = 0.021) were independent determinants of DCAN; the risk of DCAN increased by approximately 65% and 27% with each increase in the standard deviation (SD) of FAR (OR per SD, 95% CI: 1.65, 1.29-2.11, P < 0.001) and FPR (OR per SD, 95% CI: 1.27, 1.04-1.56, P = 0.021).Conclusion: FAR and FPR are independent risk factors and may influence DCAN development through inflammation."

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