"Characteristics of human papillomavirus prevalence and infection patterns among women aged 25-64 according to age groups and cytology results in Ordos City, China"

作者全名："Wang, Sumeng; Liu, Shujun; Tan, Sensen; Yin, Jian; Li, Yufei; Zhao, Fanghui; Qiao, Youlin"

作者地址："[Wang, Sumeng; Liu, Shujun; Zhao, Fanghui] Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Canc Ctr, Natl Clin Res Ctr Canc, Beijing 100021, Peoples R China; [Tan, Sensen] Chongqing Med Univ, Sch Publ Hlth, Chongqing 400016, Peoples R China; [Yin, Jian; Qiao, Youlin] Chinese Acad Med Sci & Peking Union Med Coll, Ctr Global Hlth, Sch Populat Med & Publ Hlth, Beijing 100730, Peoples R China; [Li, Yufei] Xiamen Univ, Natl Inst Diagnost & Vaccine Dev Infect Dis, State Key Lab Mol Vaccinol & Mol Diagnost, Sch Publ Hlth, Xiamen 361102, Fujian, Peoples R China"

通信作者："Zhao, FH (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Canc Ctr, Natl Clin Res Ctr Canc, Beijing 100021, Peoples R China.; Qiao, YL (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Ctr Global Hlth, Sch Populat Med & Publ Hlth, Beijing 100730, Peoples R China."

来源：VIROLOGY JOURNAL

ESI学科分类：MICROBIOLOGY

WOS号：WOS:001138260700002

JCR分区：Q2

影响因子：4.8

年份：2024

卷号：21

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Human papillomavirus (HPV); Genotype; Cervical cancer; Cytology; China

摘要："Background The assessment of human papillomavirus (HPV) genotype distribution in terms of age and cervical lesions could contribute to the adoption of more targeted preventive approaches to specific populations against cervical cancer. The current study was conducted in Ordos City, China, with the aim of analyzing the HPV genotypes prevalence and infection patterns within a hospital-based population.Methods The analysis included a total of 26,692 women aged 25-64 who underwent cervical cancer screening between January 1st, 2019, and June 30th, 2022, in Ordos City. These women had valid results for both the polymerase chain reaction (PCR)-reverse dot blot (RDB) HPV test and the liquid-based cytology (thinprep cytologic test/TCT). Data were extracted from the database of KingMed Diagnostics laboratories. The prevalence of HPV genotypes within different age groups and cytology diagnoses were calculated.Results Among 26,692 women, 7136 (26.73%) women were HPV positive, 5696 (21.34%) women were high-risk HPV (HR-HPV) positive, and 2102 (7.88%) women had multiple HPV infections. The most frequently detected HPV genotypes were HPV16 (4.72%) and HPV52 (4.15%), ranking as the first and second most prevalent genotypes, respectively. The prevalence of HR-HPV increased with age groups and severity of cervical lesions. Notably, the positive rate of HR-HPV among women aged 35-64 years showed a decreasing trend over the respective years, ranging from 26.00 to 19.70% (P-trend < 0.001).Conclusion In conclusion, the epidemiology of HPV genotypes partly reflects the effectiveness of regional cervical cancer prevention and control efforts in the past. These findings can inform future initiatives concerning HPV vaccination and screening in the region."

基金机构：CAMS Innovation Fund for Medical Sciences (CAMS) [2021-I2M-1-004]; Bill and Melinda Gates Foundation to the Chinese Academy of Medical Sciences & Peking Union Medical College [INV-006373]; Bill and Melinda Gates Foundation [INV-006373] Funding Source: Bill and Melinda Gates Foundation

基金资助正文：This study was supported by CAMS Innovation Fund for Medical Sciences (CAMS 2021-I2M-1-004) and the Bill and Melinda Gates Foundation to the Chinese Academy of Medical Sciences & Peking Union Medical College (INV-006373).