A review on recent advances in assays for DNMT1: a promising diagnostic biomarker for multiple human cancers

作者全名："Yu, Yang; Fu, Wen; Xie, Yaxing; Jiang, Xue; Wang, Hong; Yang, Xiaolan"

作者地址："[Yu, Yang; Wang, Hong] QianWei Peoples Hosp, Dept Lab Med, Leshan 614400, Peoples R China; [Fu, Wen] Chongqing Univ Canc Hosp, Dept Thorac Surg, Chongqing 400030, Peoples R China; [Yu, Yang; Xie, Yaxing; Yang, Xiaolan] Chongqing Med Univ, Coll Lab Med, Key Lab Med Lab Diagnost, Educ Minist, Chongqing 400016, Peoples R China; [Jiang, Xue] Sichuan Univ, West China Hosp, Dept Lab Med, Chengdu 610041, Sichuan, Peoples R China"

通信作者："Yang, XL (通讯作者)，Chongqing Med Univ, Coll Lab Med, Key Lab Med Lab Diagnost, Educ Minist, Chongqing 400016, Peoples R China."

来源：ANALYST

ESI学科分类：CHEMISTRY

WOS号：WOS:001140064300001

JCR分区：Q2

影响因子：3.6

年份：2024

卷号：149

期号：4

开始页：1002

结束页：1021

文献类型：Review; Early Access

关键词：　

摘要："The abnormal expression of human DNA methyltransferases (DNMTs) is closely related with the occurrence and development of a wide range of human cancers. DNA (cytosine-5)-methyltransferase-1 (DNMT1) is the most abundant human DNA methyltransferase and is mainly responsible for genomic DNA methylation patterns. Abnormal expression of DNMT1 has been found in many kinds of tumors, and DNMT1 has become a valuable target for the diagnosis and drug therapy of diseases. Nowadays, DNMT1 has been found to be involved in multiple cancers such as pancreatic cancer, breast cancer, bladder cancer, lung cancer, gastric cancer and other cancers. In order to achieve early diagnosis and for scientific research, various analytical methods have been developed for qualitative or quantitative detection of low-abundance DNMT1 in biological samples and human tumor cells. Herein, we provide a brief explication of the research progress of DNMT1 involved in various cancer types. In addition, this review focuses on the types, principles, and applications of DNMT1 detection methods, and discusses the challenges and potential future directions of DNMT1 detection. The abnormal expression of human DNA methyltransferases (DNMTs) is closely related with the occurrence and development of a wide range of human cancers."

基金机构：Natural Science Foundation of Chongqing [82273900]; National Natural Science Foundation of China [CSTB2023NSCQ-MSX0994]; Natural Science Foundation of Chongqing [20210132]; Science and Technology Planning Project of Yuzhong District of Chongqing City

基金资助正文："This study was supported by the National Natural Science Foundation of China (#82273900), the Natural Science Foundation of Chongqing (#CSTB2023NSCQ-MSX0994), and the Science and Technology Planning Project of Yuzhong District of Chongqing City under Grant No. 20210132."