Differentiation Potential of Hypodifferentiated Subsets of Nephrogenic Rests and Its Relationship to Prognosis in Wilms Tumor

作者全名："Liu, Maolin; Lu, Jiandong; Yu, Chengjun; Zhao, Jie; Wang, Ling; Hu, Yang; Chen, Long; Han, Rong; Liu, Yan; Sun, Miao; Wei, Guanghui; Wu, Shengde"

作者地址："[Liu, Maolin; Lu, Jiandong; Yu, Chengjun; Zhao, Jie; Wang, Ling; Hu, Yang; Chen, Long; Han, Rong; Liu, Yan; Sun, Miao; Wei, Guanghui; Wu, Shengde] chongqing Med Univ, Chongqing Key Lab Pediat,Minist Educ,Dept Urol, Key Lab child Dev & disorders,Natl Clin Res Ctr ch, Chongqing Key Lab Children Urogenital Dev & Tissue, chongqing, Peoples R China; [Wu, Shengde] room 806,Kejiao Bldg 6,136,Zhongshan 2nd Rd, Chongqing 400014, Peoples R China"

通信作者："Wu, SD (通讯作者)，room 806,Kejiao Bldg 6,136,Zhongshan 2nd Rd, Chongqing 400014, Peoples R China."

来源：FETAL AND PEDIATRIC PATHOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001142277800001

JCR分区：Q4

影响因子：0.7

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Wilms tumor; nephrogenic rests; tumor cell differentiation; biomarker; prognosis

摘要："Background Wilms tumor (WT) is highly curable, although anaplastic histology or relapse imparts a worse prognosis. Nephrogenic rests (NR) associated with a high risk of developing WT are abnormally retained embryonic kidney precursor cells. Methods After pseudo-time analysis using single-cell RNA sequencing (scRNA-seq) data, we generated and validated a WT differentiation-related gene (WTDRG) signature to predict overall survival (OS) in children with a poor OS. Results A differentiation trajectory from NR to WT was identified and showed that hypodifferentiated subsets of NR could differentiate into WT. Classification of WT children with anaplastic histology or relapse based on the expression patterns of WTDRGs suggested that patients with relatively high levels of hypodifferentiated NR presented a poorer prognosis. A WTDRG-based risk model and a clinically applicable nomogram was developed. Conclusions These findings may inform oncogenesis of WT and interventions directed toward poor prognosis in WT children of anaplastic histology or relapse."

基金机构："National Natural Science Foundation of China [82071632]; Innovation Program for Chongqing's Overseas Returnees [cx2019030]; Senior Medical Talents Program of Chongqing for Young and Middle-Aged and the Program for Youth Innovation in Future Medicine, Chongqing Medical University [W0069]"

基金资助正文："This work was supported by the National Natural Science Foundation of China [No. 82071632], the Innovation Program for Chongqing's Overseas Returnees [cx2019030], the Senior Medical Talents Program of Chongqing for Young and Middle-Aged and the Program for Youth Innovation in Future Medicine, Chongqing Medical University [W0069]."