Piezocatalytic strategy facilitates diabetic bone regeneration through high-performance anti-oxidative recycling

作者全名："Sun, Jiwei; Zhang, Junyuan; Yang, Lina; Zhang, Cencen; Wang, Yifan; Lei, Haoqi; Wo, Keqi; Fan, Wenjie; Zhao, Baoying; Wang, Jinyu; Shi, Yunsong; Luo, Zhiqiang; Su, Bin; Song, Jinlin; Chu, Yingying; Chen, Lili"

作者地址："[Sun, Jiwei; Zhang, Junyuan; Lei, Haoqi; Wo, Keqi; Fan, Wenjie; Zhao, Baoying; Chen, Lili] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Stomatol, Wuhan 430022, Peoples R China; [Sun, Jiwei; Zhang, Junyuan; Wang, Yifan; Lei, Haoqi; Wo, Keqi; Fan, Wenjie; Zhao, Baoying; Wang, Jinyu; Shi, Yunsong; Chen, Lili] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Stomatol, Wuhan 430030, Peoples R China; [Sun, Jiwei; Zhang, Junyuan; Wang, Yifan; Lei, Haoqi; Wo, Keqi; Fan, Wenjie; Zhao, Baoying; Wang, Jinyu; Shi, Yunsong; Chen, Lili] Hubei Prov Key Lab Oral & Maxillofacial Dev & Rege, Wuhan 430022, Peoples R China; [Yang, Lina; Zhang, Cencen; Chu, Yingying] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Peoples R China; [Luo, Zhiqiang] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Natl Engn Res Ctr Nanomed, Wuhan 430074, Peoples R China; [Su, Bin] Huazhong Univ Sci & Technol, Sch Mat Sci & Engn, State Key Lab Mat Proc & Die & Mould Technol, Wuhan 430074, Peoples R China; [Song, Jinlin] Chongqing Med Univ, Stomatol Hosp Affiliated, Chongqing 401147, Peoples R China; [Chen, Lili] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Stomatol, 1277 Jiefang Ave, Wuhan 430022, Peoples R China"

通信作者："Chen, LL (通讯作者)，Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Stomatol, Wuhan 430030, Peoples R China.; Chen, LL (通讯作者)，Hubei Prov Key Lab Oral & Maxillofacial Dev & Rege, Wuhan 430022, Peoples R China.; Chu, YY (通讯作者)，Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Peoples R China.; Song, JL (通讯作者)，Chongqing Med Univ, Stomatol Hosp Affiliated, Chongqing 401147, Peoples R China.; Chen, LL (通讯作者)，Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Stomatol, 1277 Jiefang Ave, Wuhan 430022, Peoples R China."

来源：CHEMICAL ENGINEERING JOURNAL

ESI学科分类：ENGINEERING

WOS号：WOS:001142415100001

JCR分区：Q1

影响因子：15.1

年份：2024

卷号：480

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Piezocatalytic medicine; Anti-oxidative recycling; Diabetic bone regeneration

摘要："Anti-oxidative therapy for resistance of oxidative stress-induced damage has attracted substantial attention for bone regeneration under diabetic conditions. However, most anti-oxidants suffer from low efficiency due to their one-off reaction with oxidative products and rapid loss of activity. Herein, the piezoelectric nanocomposite with built-in electric field was fabricated as a cyclic anti-oxidative device for improved reactive oxygen species (ROS) scavenging and pro-osteogenic outcome. Under ultrasound (US) irradiation, the polydopamine (PDA) -functionalized generator with piezocatalytic effect exhibits high-performance recycling of redox catalytic reaction via continuous electron supplementation for cyclic group switch from quinone to phenol. The piezocatalytic method substantially boosts ROS elimination and reverses inflammatory status, contributing to strengthened osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and M2 polarization of macrophages. In vivo results further validated superior bone healing in rats with diabetes mellitus (DM). Our study therefore provides fundamental insights into the potential value of piezocatalytic effect-triggered cyclic anti-oxidative function for optimized osteogenesis under DM condition, and lays a basis for application of piezocatalytic effect in regenerative medicine."

基金机构：National Key R & D Program of China [2021YFC2400400/04]; National Natural Science Foundation of China for Key Program Projects [82030070]

基金资助正文："This project was supported in part by grants from the National Key R & D Program of China (2021YFC2400400/04, to LC) , the National Natural Science Foundation of China for Key Program Projects (82030070, to LC) ."