The association between high-oxygen saturation and prognosis for intracerebral hemorrhage

作者全名："Zhao, Yu-tong; Yuan, Ye; Tang, Yu-guang; Zhang, Shu-wei; Zhou, Hai; Xie, Zong-yi"

作者地址："[Zhao, Yu-tong; Yuan, Ye; Tang, Yu-guang; Zhou, Hai; Xie, Zong-yi] Chongqing Med Univ, Affiliated Hosp 2, Dept Neurosurg, 76 Linjiang Rd, Chongqing 400010, Peoples R China; [Zhang, Shu-wei] Chongqing Med Univ, Affiliated Hosp 2, Dept Intens Care Unit, Chongqing 400010, Peoples R China"

通信作者："Xie, ZY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Neurosurg, 76 Linjiang Rd, Chongqing 400010, Peoples R China."

来源：NEUROSURGICAL REVIEW

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001142420400001

JCR分区：Q2

影响因子：2.8

年份：2024

卷号：47

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Oxygen saturation; SpO(2); Oxygen therapy; Spontaneous intracerebral hemorrhage; Mortality

摘要："Background Concerns about the adverse effects of excessive oxygen have grown over the years. This study investigated the relationship between high oxygen saturation and short-term prognosis of patients with spontaneous intracerebral hemorrhage (sICH) after liberal use of oxygen.Methods This retrospective cohort study collected data from the Medical Information Mart for Intensive Care III (MIMIC-III) database (ICU cohort) and a tertiary stroke center (general ward cohort). The data on pulse oximetry-derived oxygen saturation (SpO(2)) during the first 24 h in ICU and general wards were respectively extracted.Results Overall, 1117 and 372 patients were included in the ICU and general ward cohort, respectively. Among the patients from the ICU cohort, a spoon-shaped association was observed between minimum SpO(2) and the risk of in-hospital mortality (non-linear P<0.0001). In comparison with minimum SpO(2) of 93-97%, the minimum SpO(2)>97% was associated with a significantly higher risk of in-hospital mortality after adjustment for confounders. Sensitivity analysis conducted using propensity score matching did not change this significance. The same spoon-shaped association between minimum SpO(2) and the risk of in-hospital mortality was also detected for the general ward cohort. In comparison with the group with 95-97% SpO(2), the group with SpO(2)>97% showed a stronger association with, but non-significant risk for, in-hospital mortality after adjustment for confounders. The time-weighted average SpO(2)>97% was associated significantly with in-hospital mortality in both cohorts.Conclusion Higher SpO(2) (especially a minimum SpO(2)>97%) was unrewarding after liberal use of oxygen among patients with sICH and might even be potentially detrimental."

基金机构：Senior Medical Talents Program of Chongqing for Young and Middle-aged

基金资助正文：This study was funded by the Senior Medical Talents Program of Chongqing for Young and Middle-aged.