Diabetes mellitus and prostate cancer risk: A mendelian randomization analysis

作者全名："Yuan, Jian-Xu; Jiang, Qing; Yu, Sheng-Jie"

作者地址："[Yuan, Jian-Xu; Jiang, Qing; Yu, Sheng-Jie] Chongqing Med Univ, Affiliated Hosp 2, Dept Surg, Chongqing 400010, Peoples R China; [Yu, Sheng-Jie] Chongqing Med Univ, Affiliated Hosp 2, Dept Surg, 74-76 Linjiang Rd, Chongqing 400010, Peoples R China"

通信作者："Yu, SJ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Surg, 74-76 Linjiang Rd, Chongqing 400010, Peoples R China."

来源：WORLD JOURNAL OF DIABETES

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001143036200009

JCR分区：Q1

影响因子：4.2

年份：2023

卷号：14

期号：12

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结束页：　

文献类型：Article

关键词：Prostate cancer; Diabetes mellitus; Mendelian randomization analysis; Risk factors; Genome-wide association study

摘要："BACKGROUNDSome studies have directed towards an association between diabetes mellitus (DM) and prostate cancer (PCa); however, this specific relationship remains inconclusive. In recent years, Mendelian randomization (MR) has become a widely used analytical method for inferring epidemiological causes.AIMTo investigated the potential relationship between DM and PCa using MR.METHODSWe downloaded relevant data on ""diabetes"" and ""PCa"" from the IEU OpenGWAS project database, performed three different methods to conduct MR, and carried out sensitivity analysis for verification.RESULTSThe results indicated that DM was an independent risk factor for PCa. The odds ratio (OR) values obtained using the inverse variance weighted method in this study were as follows: OR = 1.018 (95% confidence interval: 1.004-1.032), P = 0.014.CONCLUSIONWe found that DM could increase the incidence rate of PCa."

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