Evidence for ethnicity and location as regulators of the newborn blood metabolome: a monozygous twin study

作者全名："Jiang, Huimin; Han, Ting-Li; Yang, Jing; Yang, Yang; Wang, Fengdi; Chen, Yuelu; Huang, Nana; Mansell, Toby; Craig, Jeffrey M.; Scurrah, Katrina J.; Novakovic, Boris; Baker, Philip N.; Zhang, Hua; Wei, Yuan; Wang, Lianlian; Saffery, Richard"

作者地址："[Jiang, Huimin; Wang, Fengdi; Chen, Yuelu; Wang, Lianlian] Chongqing Med Univ, Dept Reprod Med Ctr, Affiliated Hosp 1, Chongqing, Peoples R China; [Han, Ting-Li] Chongqing Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 2, Chongqing, Peoples R China; [Yang, Jing; Huang, Nana; Wei, Yuan] Peking Univ Third Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China; [Yang, Yang; Zhang, Hua] Chongqing Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 1, Chongqing, Peoples R China; [Yang, Yang; Zhang, Hua] Chongqing Med Univ, Chongqing Key Lab Maternal & Fetal Med, Chongqing, Peoples R China; [Yang, Yang] Chongqing Med Univ, Life Sci Inst, Mass Spectrometry Ctr Maternal Fetal Med, Chongqing, Peoples R China; [Mansell, Toby; Craig, Jeffrey M.; Novakovic, Boris; Saffery, Richard] Univ Melbourne, Murdoch Childrens Res Inst, Parkville, Vic, Australia; [Mansell, Toby; Craig, Jeffrey M.; Novakovic, Boris; Saffery, Richard] Univ Melbourne, Dept Paediat, Parkville, Vic, Australia; [Craig, Jeffrey M.] Deakin Univ, Inst Mental & Phys Hlth & Clin Translat IMPACT, Sch Med, Melbourne, Vic, Australia; [Scurrah, Katrina J.] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Twins Res Australia, Melbourne, Vic, Australia; [Scurrah, Katrina J.] Univ Melbourne, Ctr Mental Hlth, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia; [Baker, Philip N.] Univ Leicester, Coll Life Sci, Leicester, England"

通信作者："Wang, LL (通讯作者)，Chongqing Med Univ, Dept Reprod Med Ctr, Affiliated Hosp 1, Chongqing, Peoples R China.; Wei, Y (通讯作者)，Peking Univ Third Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China.; Zhang, H (通讯作者)，Chongqing Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 1, Chongqing, Peoples R China.; Zhang, H (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Maternal & Fetal Med, Chongqing, Peoples R China."

来源：FRONTIERS IN NUTRITION

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001143657500001

JCR分区：Q2

影响因子：5

年份：2024

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：monochorionic diamniotic (MCDA) twins; umbilical cord blood plasma; metabolomics; shared and non-shared environmental factors; uncomplicated MCDA twins

摘要："IntroductionMonochorionic, diamniotic (MCDA) monozygotic twins share nearly all genetic variation and a common placenta in utero. Despite this, MCDA twins are often discordant for a range of common phenotypes, including early growth and birth weight. As such, MCDA twins represent a unique model to explore variation in early growth attributable primarily to in utero environmental factors.MethodsMCDA twins with a range of within-pair birth weight discordance were sampled from the peri/postnatal epigenetic twin study (PETS, Melbourne; n = 26 pairs), Beijing twin study (BTS, Beijing; n = 25), and the Chongqing longitudinal twin study (LoTiS, Chongqing; n = 22). All PETS participants were of European-Australian ancestry, while all Chinese participants had Han ancestry. The average of the birth weight difference between the larger and smaller co-twins for all twin pairs was determined and metabolomic profiles of amino acids, TCA cycle intermediates, fatty acids, organic acids, and their derivatives generated from cord blood plasma by gas chromatograph mass spectrometry. Within and between co-twin pair analyses were performed to identify metabolites specifically associated with discordance in birth weight. Multivariable regression and pathway enrichment analyses between different regions were performed to evaluate the geographical effects on the metabolism of MCDA twin pairs.ResultsPETS twins showed a markedly different metabolic profile at birth compared to the two Chinese samples. Within-pair analysis revealed an association of glutathione, creatinine, and levulinic acid with birth weight discordance. Caffeine, phenylalanine, and several saturated fatty acid levels were uniquely elevated in PETS twins and were associated with maternal BMI and average within pair birth weight, in addition to birth weight discordance. LoTiS twins had higher levels of glutathione, tyrosine, and gamma-linolenic acid relative to PETS and BTS twins, potentially associated with eating habits.ConclusionThis study highlights the potential role of underlying genetic variation (shared by MZ twins), in utero (non-shared by MZ twins) and location-specific (shared by MZ twins) environmental factors, in regulating the cord blood metabolome of uncomplicated MCDA twins. Future research is needed to unravel these complex relationships that may play a key role in phenotypic metabolic alterations of twins independent of genetic diversity."

基金机构：Joint Program of the Chongqing Science and Technology Bureau and the Chongqing Health Commission

基金资助正文：No Statement Available