Comparison of various excimer laser (EL) combination therapies for vitiligo: a systematic review and network meta-analysis

作者全名："Li, Chanxiu; Hu, Yue; Mu, Zengyi; Shi, Lei; Sun, Xiao; Wang, Xinyue; Wang, Yaping; Li, Xinhong"

作者地址："[Li, Chanxiu; Hu, Yue; Li, Xinhong] Liaoning Univ Tradit Chinese Med, Affiliated Hosp, Dept Dermatol, Shenyang, Peoples R China; [Mu, Zengyi; Sun, Xiao; Wang, Yaping] Liaoning Univ Tradit Chinese Med, Grad Sch, Shenyang, Peoples R China; [Shi, Lei] Liaoning Univ Tradit Chinese Med, Affiliated Hosp, Dept Otorhinolaryngol, Shenyang, Peoples R China; [Wang, Yaping] Chongqing Med Univ, Yongchuan Chinese Med Hosp, Dept Otorhinolaryngol, Chongqing, Peoples R China; [Li, Xinhong] Liaoning Univ Tradit Chinese Med, Affiliated Hosp, 33,Beiling St, Shenyang 110847, Liaoning, Peoples R China"

通信作者："Li, XH (通讯作者)，Liaoning Univ Tradit Chinese Med, Affiliated Hosp, 33,Beiling St, Shenyang 110847, Liaoning, Peoples R China."

来源：JOURNAL OF DERMATOLOGICAL TREATMENT

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001143828700001

JCR分区：Q2

影响因子：2.9

年份：2024

卷号：35

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：Excimer laser; vitiligo; net meta-analysis; antioxidant; repigmentation rate

摘要："AimThis study aimed to compare the efficacy and safety of excimer laser (EL)-based combination regimens in improving repigmentation.MethodsA comprehensive search was conducted in PubMed, Web of Science, Cochrane Library, and Embase on July 1, 2023, to include randomized controlled trials of EL combination treatments for vitiligo that met the criteria. The primary outcome measure was a repigmentation rate >= 75%, and the secondary outcome measures were a repigmentation rate of <= 25% and adverse events.ResultsEleven studies involving 348 patients were included. Network Meta-Analysis showed that EL combined with antioxidants (SUCRA = 98.8%), EL combined with calcipotriol (SUCRA = 59.8%) and EL combined with tacalcitol (SUCRA = 59.6%) were the three optimal interventions achieving repigmentation rates >= 75%. EL alone (SUCRA = 77.6%), EL combined with tacalcitol (SUCRA = 61.7%) and EL combined with antioxidants (SUCRA = 57.2%) were the three interventions with the highest rates of treatment failure. Adverse events in all groups mainly included erythema, burning sensation and hyperpigmentation. Based on the results of the current study, EL combination therapies were safe with mild adverse events.ConclusionEL combined with antioxidants was the preferred regimen for vitiligo, whereas EL alone was the regimen with the highest rate of treatment failure in vitiligo."

基金机构：National TCM Outstanding Talents Funding Program of the State Administration of Traditional Chinese Medicine [1]

基金资助正文：National TCM Outstanding Talents Funding Program of the State Administration of Traditional Chinese Medicine (Letter [2022] No. 1 of the State Administration of Traditional Chinese Medicine): Training Program for Clinical Outstanding Talents in TCM