Bioinspired Amino Acid Based Materials in Bionanotechnology: From Minimalistic Building Blocks and Assembly Mechanism to Applications

作者全名："Wang, Yuehui; Rencus-Lazar, Sigal; Zhou, Haoran; Yin, Yuanyuan; Jiang, Xuemei; Cai, Kaiyong; Gazit, Ehud; Ji, Wei"

作者地址："[Wang, Yuehui; Zhou, Haoran; Jiang, Xuemei; Cai, Kaiyong; Ji, Wei] Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China; [Rencus-Lazar, Sigal; Gazit, Ehud] Tel Aviv Univ, George S Wise Fac Life Sci, Sch Mol Cell Biol & Biotechnol, IL-6997801 Tel Aviv, Israel; [Yin, Yuanyuan] Chongqing Med Univ, Stomatol Hosp, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401147, Peoples R China"

通信作者："Ji, W (通讯作者)，Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China.; Gazit, E (通讯作者)，Tel Aviv Univ, George S Wise Fac Life Sci, Sch Mol Cell Biol & Biotechnol, IL-6997801 Tel Aviv, Israel.; Yin, YY (通讯作者)，Chongqing Med Univ, Stomatol Hosp, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401147, Peoples R China."

来源：ACS NANO

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:001144037000001

JCR分区：Q1

影响因子：15.8

年份：2023

卷号：18

期号：2

开始页：1257

结束页：1288

文献类型：Review

关键词：amino acids; minimalistic building blocks; self-assembly; noncovalentinteractions; nanostructures; bioinspired materials; supramolecular chemistry; bionanotechnology

摘要："Inspired by natural hierarchical self-assembly of proteins and peptides, amino acids, as the basic building units, have been shown to self-assemble to form highly ordered structures through supramolecular interactions. The fabrication of functional biomaterials comprised of extremely simple biomolecules has gained increasing interest due to the advantages of biocompatibility, easy functionalization, and structural modularity. In particular, amino acid based assemblies have shown attractive physical characteristics for various bionanotechnology applications. Herein, we propose a review paper to summarize the design strategies as well as research advances of amino acid based supramolecular assemblies as smart functional materials. We first briefly introduce bioinspired reductionist design strategies and assembly mechanism for amino acid based molecular assembly materials through noncovalent interactions in condensed states, including self-assembly, metal ion mediated coordination assembly, and coassembly. In the following part, we provide an overview of the properties and functions of amino acid based materials toward applications in nanotechnology and biomedicine. Finally, we give an overview of the remaining challenges and future perspectives on the fabrication of amino acid based supramolecular biomaterials with desired properties. We believe that this review will promote the prosperous development of innovative bioinspired functional materials formed by minimalistic building blocks."

基金机构："Israel Science Foundation [52103148]; National Natural Science Foundation of China [3145/19]; Chongqing University, Joint NSFC-ISF Grant [2020752]; Joint NSF-BSF Grant"

基金资助正文："This work was supported by the National Natural Science Foundation of China (No. 52103148), Start-up Funding from Chongqing University, Joint NSFC-ISF Grant (No. 3145/19), and Joint NSF-BSF Grant (No. 2020752)."