Contrast-enhanced CT radiomics features to preoperatively identify differences between tumor and proximal tumor-adjacent and tumor-distant tissues of resectable esophageal squamous cell carcinoma

作者全名："Gao, Dan; Tan, Bang-guo; Chen, Xiao-qian; Zhou, Chuanqinyuan; Ou, Jing; Guo, Wen-wen; Zhou, Hai-ying; Li, Rui; Zhang, Xiao-ming; Chen, Tian-wu"

作者地址："[Gao, Dan; Tan, Bang-guo; Chen, Xiao-qian; Zhou, Chuanqinyuan; Ou, Jing; Guo, Wen-wen; Zhou, Hai-ying; Li, Rui; Zhang, Xiao-ming] Affiliated Hosp, North Sichuan Med Coll, Med Imaging Key Lab Sichuan Prov, 1 Maoyuan South Rd, Nanchong 637000, Sichuan, Peoples R China; [Gao, Dan; Tan, Bang-guo; Chen, Xiao-qian; Zhou, Chuanqinyuan; Ou, Jing; Guo, Wen-wen; Zhou, Hai-ying; Li, Rui; Zhang, Xiao-ming] Affiliated Hosp, North Sichuan Med Coll, Dept Radiol, 1 Maoyuan South Rd, Nanchong 637000, Sichuan, Peoples R China; [Gao, Dan] Med Ctr Hosp Qionglai City, Dept Radiol, 172 Xinlin Rd, Chengdu 611530, Sichuan, Peoples R China; [Tan, Bang-guo] Panzhihua Cent Hosp, Dept Radiol, 34 Yikang St, Panzhihua 617067, Sichuan, Peoples R China; [Chen, Tian-wu] Chongqing Med Univ, Dept Radiol, Affiliated Hosp 2, 74 Linjiang Rd, Chongqing 400010, Peoples R China"

通信作者："Chen, TW (通讯作者)，Chongqing Med Univ, Dept Radiol, Affiliated Hosp 2, 74 Linjiang Rd, Chongqing 400010, Peoples R China."

来源：CANCER IMAGING

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001145372100001

JCR分区：Q1

影响因子：4.9

年份：2024

卷号：24

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Esophagus; Squamous cell carcinoma; Tomography; X-ray computed; Tumor-adjacent tissue; Tumor-distant tissue

摘要："BackgroundEsophagectomy is the main treatment for esophageal squamous cell carcinoma (ESCC), and patients with histopathologically negative margins still have a relatively higher recurrence rate. Contrast-enhanced CT (CECT) radiomics might noninvasively obtain potential information about the internal heterogeneity of ESCC and its adjacent tissues. This study aimed to develop CECT radiomics models to preoperatively identify the differences between tumor and proximal tumor-adjacent and tumor-distant tissues in ESCC to potentially reduce tumor recurrence.MethodsA total of 529 consecutive patients with ESCC from Centers A (n = 447) and B (n = 82) undergoing preoperative CECT were retrospectively enrolled in this study. Radiomics features of the tumor, proximal tumor-adjacent (PTA) and proximal tumor-distant (PTD) tissues were individually extracted by delineating the corresponding region of interest (ROI) on CECT and applying the 3D-Slicer radiomics module. Patients with pairwise tissues (ESCC vs. PTA, ESCC vs. PTD, and PTA vs. PTD) from Center A were randomly assigned to the training cohort (TC, n = 313) and internal validation cohort (IVC, n = 134). Univariate analysis and the least absolute shrinkage and selection operator were used to select the core radiomics features, and logistic regression was performed to develop radiomics models to differentiate individual pairwise tissues in TC, validated in IVC and the external validation cohort (EVC) from Center B. Diagnostic performance was assessed using area under the receiver operating characteristics curve (AUC) and accuracy.ResultsWith the chosen 20, 19 and 5 core radiomics features in TC, 3 individual radiomics models were developed, which exhibited excellent ability to differentiate the tumor from PTA tissue (AUC: 0.965; accuracy: 0.965), the tumor from PTD tissue (AUC: 0.991; accuracy: 0.958), and PTA from PTD tissue (AUC: 0.870; accuracy: 0.848), respectively. In IVC and EVC, the models also showed good performance in differentiating the tumor from PTA tissue (AUCs: 0.956 and 0.962; accuracy: 0.956 and 0.937), the tumor from PTD tissue (AUCs: 0.990 and 0.974; accuracy: 0.952 and 0.970), and PTA from PTD tissue (AUCs: 0.806 and 0.786; accuracy: 0.760 and 0.786), respectively.ConclusionCECT radiomics models could differentiate the tumor from PTA tissue, the tumor from PTD tissue, and PTA from PTD tissue in ESCC."

基金机构：National Natural Science Foundation of China

基金资助正文：Not applicable.