Postnatal feeding with high-fat combined with high-glucose diet induces precocious puberty in Sprague-Dawley rat pups

作者全名："Huang, Xiao-Yan; Chen, Ji-Xiong; Ren, Yi; Luo, Hai-Ling; Xiang, Wei; He, Xiao-Jie; Li, Ting -Yu"

作者地址："[Huang, Xiao-Yan; Li, Ting -Yu] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Child Nutr & Hlth, Minist Educ,Key Lab Child Dev & Disorders,Children, Chongqing, Peoples R China; [Huang, Xiao-Yan; Luo, Hai-Ling; Xiang, Wei] Hainan Women & Childrens Med Ctr, Dept Genet Metab & Endocrinol, Haikou, Hainan, Peoples R China; [Chen, Ji-Xiong] Hainan Prov Peoples Hosp, Dept Med Care Ctr, Haikou, Hainan, Peoples R China; [Ren, Yi] Haikou Maternal & Child Hlth Hosp, Dept Pediat, Haikou, Peoples R China; [He, Xiao-Jie] Cent South Univ, Xiangya Hosp 2, Dept Paediat, Changsha, Peoples R China"

通信作者："Li, TY (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Child Nutr & Hlth, Minist Educ,Key Lab Child Dev & Disorders,Children, Chongqing, Peoples R China.; Xiang, W (通讯作者)，Hainan Women & Childrens Med Ctr, Dept Genet Metab & Endocrinol, Haikou, Hainan, Peoples R China.; He, XJ (通讯作者)，Cent South Univ, Xiangya Hosp 2, Dept Paediat, Changsha, Peoples R China."

来源：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001145562500001

JCR分区：Q2

影响因子：3.1

年份：2024

卷号：693

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Obesity; Precocious puberty; High-fat diet; High-glucose diet; GnRH

摘要："With economic development and overnutrition, including high-fat diets (HFD) and high-glucose diets (HGD), the incidence of obesity in children is increasing, and thus, the incidence of precocious puberty is increasing. Therefore, it is of great importance to construct a suitable animal model of overnutrition-induced precocious puberty for further in-depth study. Here, we fed a HFD, HGD, or HFD combined with a HGD to pups after P-21 weaning, while weaned pups fed a normal diet served as the control group. The results showed that HFD combined with a HGD increased the body weight (BW) of weaned rat pups. In addition, a HFD, HGD, and HFD combined with a HGD lowered the age at which vaginal opening occurred and accelerated the vaginal cell cycle. Furthermore, a HFD combined with a HGD increased the weight of the uterus and ovaries of weaned rat pups. Additionally, a HFD combined with a HGD promoted the development of reproductive organs in weaned female rat pups. Ultimately, a HFD combined with a HGD was found to elevate the serum levels of gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), follicle stimulating hormone (FSH), leptin, adiponectin, and oestradiol (E2) and increase hypothalamic GnRH, Kiss-1, and GPR54 expression levels in weaned female rat pups. The current study found that overnutrition, such as that through a HFD combined with HGD, could induce precocious puberty in weaned female rat pups. In addition, a rat model of overnutrition-induced precocious puberty was established."

基金机构：Key Research & Development Project of Hainan Province [ZDYF2021SHFZ226]; Major Science and Technology Program of Hainan Province [ZDKJ2019010]; Hainan Province Clinical Medical Center [QWYH202175]

基金资助正文："<B>Funding</B> This work was supported by the Key Research & Development Project of Hainan Province (ZDYF2021SHFZ226) , Major Science and Technology Program of Hainan Province (ZDKJ2019010) and Hainan Province Clinical Medical Center (No. QWYH202175) ."