Connective tissue disease as a challenge in heart failure: Three case reports

作者全名："Liu, Ke; Li, Xuejiao; Li, Dan"

作者地址："[Liu, Ke; Li, Xuejiao] ChongQing Med Univ, Affiliated Hosp 2, Emergency Dept, Chongqing 400010, Peoples R China; [Li, Dan] ChongQing Med Univ, Affiliated Hosp 2, Dept Cardiol, Chongqing 400010, Peoples R China"

通信作者："Li, D (通讯作者)，ChongQing Med Univ, Affiliated Hosp 2, Dept Cardiol, Chongqing 400010, Peoples R China."

来源：MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001145855300064

JCR分区：Q2

影响因子：1.6

年份：2024

卷号：103

期号：3

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结束页：　

文献类型：Article

关键词：anti-synthetase syndrome; catastrophic antiphospholipid syndrome; connective tissue disease; heart failure; Takayasu arteritis

摘要："Rationale: Connective tissue disease (CTD) is a heterogeneous group of chronic inflammatory autoimmune disorders derived from a systemically auto-immunological deregulation. CTD may affect cardiac structures through multiple pathophysiological mechanisms, and subclinical cardiac injury is common. Heart failure (HF) is one of the common complications in these patients. Patient concerns: Patients with CTD suffer an increased risk of cardiovascular disease and may have chest pain and shortness of breath. Diagnosis: HF is characterized by dyspnea or exertional limitation due to impaired ventricular filling and/or blood ejection. HF can be caused by other systemic diseases, not only by cardiovascular disorders but CTD. CTD may cause HF due to diffuse myocardial damage, heart valve damage, coronary ischemia, and so on. Interventions: The patient with catastrophic antiphospholipid syndrome take prednisone and warfarin. The patient with anti-synthetase syndrome was treated with immunoglobulin, followed by long-term oral medicines of prednisone, methotrexate, and folic acid. Outcomes: The symptoms of chest pain and shortness of breath for patients with CTD improved. Lessons: HF is one of the common complications in these patients with CTD, which has poor prognosis and severe aggravation. Once such patients experience chest pain, chest tightness, shortness of breath, etc, we should consider the possibility of HF. Early identification and correct treatment can delay the progression of HF, improve the prognosis, and enhance the quality of life for patients. Therefore, we should pay more attention to patients with CTD combined with HF."

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