An immune-related prognostic gene ULBP2 is correlated with immunosuppressive tumor microenvironment and immunotherapy in breast cancer

作者全名："Feng, Rui; Xu, Jiali; Huang, Jing; Liu, Jiazhou; Wang, Xiaoyu; Wang, Jing; Zhang, Chong; Li, Hongzhong; Wei, Yuxian; Ren, Guosheng"

作者地址："[Feng, Rui; Xu, Jiali; Liu, Jiazhou; Wang, Xiaoyu; Wang, Jing; Zhang, Chong; Li, Hongzhong; Ren, Guosheng] Chongqing Med Univ, Affiliated Hosp 1, Chongqing Key Lab Mol Oncol & Epigenet, Chongqing 400016, Peoples R China; [Feng, Rui; Xu, Jiali; Liu, Jiazhou; Wang, Xiaoyu; Wang, Jing; Wei, Yuxian; Ren, Guosheng] Chongqing Med Univ, Affiliated Hosp 1, Dept Breast & Thyroid Surg, Chongqing 400016, Peoples R China; [Huang, Jing] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing 400016, Peoples R China; [Zhang, Chong] Chongqing Med Univ, Dept Ultrasound, Affiliated Hosp 1, Chongqing 400016, Peoples R China"

通信作者："Ren, GS (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Chongqing Key Lab Mol Oncol & Epigenet, Chongqing 400016, Peoples R China.; Wei, YX; Ren, GS (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Breast & Thyroid Surg, Chongqing 400016, Peoples R China."

来源：HELIYON

ESI学科分类：　

WOS号：WOS:001146009200001

JCR分区：Q2

影响因子：4

年份：2024

卷号：10

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：ULBP2; Breast cancer; Immune genes; Prognostic model; Tumor microenvironment status; Immunotherapy effect prediction

摘要："Breast cancer (BC) is one of the major dangerous tumors threatening women's lives. We here aimed to sort out prognostic immune-related genes by univariate Cox regression analysis and build a model of immune-related genes for forecasting the prognosis of BC patients. We identified UL16 binding protein 2 (ULBP2) as a valuable gene for study in the model using related databases and algorithms analysis. We found the stromal and immune cells scores were higher in ULBP2 high expression group and ULBP2 was related to kinds of immune cells, most importantly had negative correlation with CD8+ T cell. Notably, ULBP2 was positively correlated with tumor mutational burden (TMB) and had relationship with many immune checkpoints. Correlation analysis revealed that ULBP2 expression was closely linked to the clinicopathological characters and negatively related to BC patient survival. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis showed the functional enrichment of differential genes related to ULBP2. Gene Set Enrichment Analysis (GSEA) indicated pathway enrichment in ULBP2 high and low expression groups. In short, this study comprehensively investigated the potential function of ULBP2 in BC, which might make ULBP2 to be an important therapeutic target for BC."

基金机构："National Natural Science Foundation of China [82173166, 81472475, 81902343]; Natural Science Foundation of Chongqing [cstc2021jcyj-msxmX0015]; CQMU Program for Youth Innovation in Future Medicine [W0094]"

基金资助正文："Thanks to the TCGA for providing the original data. And This work was supported by the National Natural Science Foundation of China [grant numbers No. 82173166, 81472475 and 81902343] ; Natural Science Foundation of Chongqing [grant numbers cstc2021jcyj-msxmX0015] ; and CQMU Program for Youth Innovation in Future Medicine [grant numbers NO.W0094] ."