A Machine Learning Method for Predicting Biomarkers Associated with Prostate Cancer
作者全名："Tong, Yanqiu; Tan, Zhongle; Wang, Pu; Gao, Xi"
作者地址："[Tong, Yanqiu] Chongqing Med Univ, Lab Forens Med & Biomed Informat, Chongqing 400016, Peoples R China; [Tong, Yanqiu] Chongqing Jiaotong Univ, Sch Tourism & Media, Chongqing 400074, Peoples R China; [Tan, Zhongle] Chongqing Three Gorges Med Coll, Sch Tradit Chinese Med, Chongqing 404120, Peoples R China; [Wang, Pu] Army Med Univ, Third Mil Med Univ, Southwest Hosp, Dept Rehabil, Chongqing 400038, Peoples R China; [Gao, Xi] Chongqing Med Univ, Univ Town Hosp, Dept Tradit Chinese Med, Chongqing 400016, Peoples R China"
通信作者："Tong, YQ (通讯作者)，Chongqing Med Univ, Lab Forens Med & Biomed Informat, Chongqing 400016, Peoples R China.; Tong, YQ (通讯作者)，Chongqing Jiaotong Univ, Sch Tourism & Media, Chongqing 400074, Peoples R China."
来源：FRONTIERS IN BIOSCIENCE-LANDMARK
ESI学科分类：
WOS号：WOS:001146038600004
JCR分区：Q2
影响因子：3.3
年份：2023
卷号：28
期号：12
开始页：
结束页：
文献类型：Article
关键词：machine learning; prostate cancer; prognostic biomarker; prognostic model; drug targets
摘要："Background: Prostate cancer (PCa) is a prevalent form of malignant tumors affecting the prostate gland and is frequently diagnosed in males in Western countries. Identifying diagnostic and prognostic biomarkers is not only important for screening drug targets but also for understanding their pathways and reducing the cost of experimental verification of PCa. The objective of this study was to identify and validate promising diagnostic and prognostic biomarkers for PCa. Methods: This study implemented a machine learning technique to evaluate the diagnostic and prognostic biomarkers of PCa using protein-protein interaction (PPI) networks. In addition, multi-database validation and literature review were performed to verify the diagnostic biomarkers. To optimize the prognosis of our results, univariate Cox regression analysis was utilized to screen survival-related genes. This study employed stepwise multivariate Cox regression analysis to develop a prognostic risk model. Finally, receiver operating characteristic analysis confirmed that these predictive biomarkers demonstrated a substantial level of sensitivity and specificity when predicting the prognostic survival of patients. Results: The hub genes were UBE2C (Ubiquitin Conjugating Enzyme E2 C), CCNB1 (Cyclin B1), TOP2A (DNA Topoisomerase II Alpha), NPY (Neuropeptide Y), and TRIM36 (Tripartite Motif Containing 36). All of these hub genes were validated by multiple databases. By validation in these databases, these 10 hub genes were significantly involved in significant pathways. The risk model was constructed by a four-gene-based prognostic factor that included TOP2A, UBE2C, MYL9, and FLNA. Conclusions: The machine learning algorithm combined with PPI networks identified hub genes that can serve as diagnostic and prognostic biomarkers for PCa. This risk model will enable patients with PCa to be more accurately diagnosed and predict new drugs in clinical trials."
基金机构：Chongqing Language and Writing Research Project [yyk21213]; Chongqing Natural Science Foundation General Project [cstc2021jcyj- msxmX0485]; Humanities & social sciences of the Ministry of Education of the People's Republic of China [19YJA860022]; Basic science and frontier project of Chongqing Municipal Science and Technology Commission [cstc2016jcyjA0582]
基金资助正文："This work was funded by Chongqing Language and Writing Research Project (yyk21213) , Chongqing Natural Science Foundation General Project (cstc2021jcyj- msxmX0485) , Humanities & social sciences of the Ministry of Education of the People's Republic of China (19YJA860022) and Basic science and frontier project of Chongqing Municipal Science and Technology Commission (cstc2016jcyjA0582) ."
