Serum Ferritin is a Novel Predictive Marker for Breast Cancer Metastasis and the Combination with CA153 Optimizes Metastasis Monitoring

作者全名："Yao, Xufeng; Sha, Hezhang; He, Xiang; Gan, Lu; Wang, Xiaoyi; Cheng, Qiao"

作者地址："[Yao, Xufeng; Sha, Hezhang; Wang, Xiaoyi; Cheng, Qiao] Chongqing Med Univ, Affiliated Hosp 1, Dept Breast & Thyroid Surg, Chongqing 400016, Peoples R China; [He, Xiang] Chongqing Med Univ, Affiliated Hosp 1, Hlth Management Ctr, Chongqing 400016, Peoples R China; [Gan, Lu] Chongqing Med Univ, Affiliated Hosp 1, Dept Oncol, Chongqing 400016, Peoples R China"

通信作者："Cheng, Q (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Breast & Thyroid Surg, Chongqing 400016, Peoples R China."

来源：JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001148081000001

JCR分区：Q4

影响因子：0.8

年份：2024

卷号：38

期号：1

开始页：635

结束页：645

文献类型：Article

关键词：serum ferritin; breast cancer; predictive biomarkers; metastasis prediction

摘要："Background: Breast cancer has become the most common cancer worldwide. Early detection of metastatic events is vital for improving survival. Currently, the serum tumor markers for monitoring metastatic breast cancer in clinic practice are carbohydrate antigen (CA153) and carcinoembryonic antigen (CEA) based on the 2007 edition of American Society of Clinical Oncology (ASCO) guidelines. This study aims to identify more specific, sensitive, and cost-effective tumor markers to improve the accuracy of predicting distant metastasis of breast cancer.Methods: A total of 468 breast cancer patients, including 170 patients with distant metastasis and 298 without metastasis, were retrospectively reviewed. The levels of the serum tumor markers ferritin, CA153, and CEA in both the metastasis and nonmetastasis groups, in subgroups of different pathologic types, different metastatic sites, and different tumor burden, were analyzed via one-way analysis of variance and the receiver operating characteristics (ROC) curve. The differences between ROC curves were compared using the paired comparison method.Results: High serum ferritin levels predict distant breast cancer metastasis with the highest specificity and sensitivity among all three markers, especially in hormone receptor (HR)-/ human epidermal growth factor receptor 2 (Her2)+ and HR-/Her2- molecular subtypes. The prediction accuracy for metastasis increased when a combination of two or all three markers, and the combination of ferritin and CA153 could be the optimal choice to maximize the efficiency and predictive ability for metastasis. The baseline levels of all three markers were associated with metastasis tumor burden and could be more sensitive in predicting patients with liver metastasis than patients with lung and bone metastases.Conclusions: The findings obtained from this study suggest that serum ferritin is a putative candidate as a non-invasive biomarker for monitoring breast cancer metastasis that is even more sensitive and specific than the traditional breast tumor markers CA153 and CEA. However, further studies with a more extensive set of patient data are needed to validate the conclusions."

基金机构：Chongqing Health Commission; Chongqing Science and Technology Bureau [2021MSXM333]

基金资助正文：This work was supported by The Joint MedicalResearch Project from the Chongqing Health Commission and Chongqing Science and Technology Bureau (2021MSXM333).