Risk assessment for postoperative venous thromboembolism using the modified Caprini risk assessment model in lung cancer

作者全名："Ding, Yao; Yao, Lijun; Tan, Tao; Li, Qiang; Shi, Haoming; Tian, Yuan; Franssen, Aimee J. P. M.; de Loos, Erik R.; Al Zaidi, Muteb; Cardillo, Giuseppe; Kidane, Biniam; Grapatsas, Konstantinos; Wu, Qingchen; Zhang, Cheng"

作者地址："[Ding, Yao; Yao, Lijun; Li, Qiang; Shi, Haoming; Wu, Qingchen; Zhang, Cheng] Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiothorac Surg, 1 Youyi Rd, Chongqing 400000, Peoples R China; [Ding, Yao] Peoples Hosp Kaizhou Dist, Dept Thorac Surg, Chongqing, Peoples R China; [Tan, Tao] Chongqing Hlth Stat Informat Ctr, Chongqing, Peoples R China; [Tian, Yuan] Chongqing Med Univ, Affiliated Hosp 1, Dept Med Affairs, Chongqing, Peoples R China; [Franssen, Aimee J. P. M.; de Loos, Erik R.] Zuyderland Med Ctr, Dept Surg, Div Gen Thorac Surg, Heerlen, Netherlands; [Al Zaidi, Muteb] King Abdullah Med City, Thorac Surg Unit, Mecca, Saudi Arabia; [Cardillo, Giuseppe] San Camillo Forlanini Hosp, Unit Thorac Surg, Rome, Italy; [Cardillo, Giuseppe] Unicamillus St Camillus Univ Hlth Sci, Rome, Italy; [Kidane, Biniam] Univ Manitoba, Sect Thorac Surg, Winnipeg, MB, Canada; [Grapatsas, Konstantinos] Univ Duisburg Essen, Ruhrlandklin, Dept Thorac Surg, Essen, Germany"

通信作者："Zhang, C (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiothorac Surg, 1 Youyi Rd, Chongqing 400000, Peoples R China."

来源：JOURNAL OF THORACIC DISEASE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001148625000047

JCR分区：Q3

影响因子：2.1

年份：2023

卷号：15

期号：6

开始页：3386

结束页：3396

文献类型：Article

关键词：Venous thromboembolism (VTE); lung cancer; the modified Caprini risk assessment model; risk factor

摘要："Background: Postoperative venous thromboembolism (VTE) is a well-documented cause of morbidity and mortality in lung cancer patients. However, risk identification remains limited. In this study, we sought to analyze the risk factors for VTE and verify the predictive value of the modified Caprini risk assessment model (RAM). Methods: This prospective single-center study included patients with resectable lung cancer who underwent resection between October 2019 and March 2021. The incidence of VTE was estimated. Logistic regression was used to analyze the risk factors for VTE. Receiver operating characteristic (ROC) curve analysis was performed to test the ability of the modified Caprini RAM to predict VTE. Results: The VTE incidence was 10.5%. Several variables, including age, D-dimer, hemoglobin (Hb), bleeding, and patient confinement to bed were significantly associated with VTE after surgery. The difference between the VTE and non-VTE groups in the high-risk levels was statistically significant (P<0.001), while the low and moderate risk levels showed no significant difference. The combined use of the modified Caprini score and the Hb and D-dimer levels showed an area under the curve (AUC) was 0.822 [95% confidence interval (CI): 0.760-0.855. P<0.001]. Conclusions: The risk-stratification approach of the modified Caprini RAM is not particularly valid after lung resection in our population. The use of the modified Caprini RAM combined with Hb and D-dimer levels shows a good diagnostic performance for VTE prediction in patients with lung cancer undergoing resection."

基金机构：Chongqing Medical Scientific Research Project [2020MSXM131]

基金资助正文：This work was supported by the Chongqing Medical Scientific Research Project (No. 2020MSXM131).