Recent advances of mechanosensitive genes in vascular endothelial cells for the formation and treatment of atherosclerosis

作者全名："Li, Shuyu; Xu, Zichen; Wang, Yi; Chen, Lizhao; Wang, Xiangxiu; Zhou, Yanghao; Lei, Daoxi; Zang, Guangchao; Wang, Guixue"

作者地址："[Li, Shuyu; Xu, Zichen; Wang, Xiangxiu; Zhou, Yanghao; Lei, Daoxi; Wang, Guixue] Chongqing Univ, Key Lab Biorheol Sci & Technol, Natl & Local Joint Engn Lab Vasc Implants, Minist Educ,Bioengn Coll, Chongqing 400030, Peoples R China; [Wang, Yi; Zang, Guangchao] Chongqing Med Univ, Coll Basic Med Sci, Chongqing 400016, Peoples R China; [Chen, Lizhao] Army Med Univ, Daping Hosp, Army Med Ctr PLA, Dept Neurosurg, Chongqing 400042, Peoples R China"

通信作者："Wang, GX (通讯作者)，Chongqing Univ, Key Lab Biorheol Sci & Technol, Natl & Local Joint Engn Lab Vasc Implants, Minist Educ,Bioengn Coll, Chongqing 400030, Peoples R China.; Zang, GC (通讯作者)，Chongqing Med Univ, Coll Basic Med Sci, Chongqing 400016, Peoples R China."

来源：GENES & DISEASES

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001150341400001

JCR分区：Q1

影响因子：6.9

年份：2024

卷号：11

期号：3

开始页：　

结束页：　

文献类型：Article

关键词：Atherosclerosis; Blood flow; Endothelial cell; Mechanosensitive gene; Therapeutic target

摘要："Atherosclerotic cardiovascular disease and its complications are a high-incidence disease worldwide. Numerous studies have shown that blood flow shear has a huge impact on the function of vascular endothelial cells, and it plays an important role in gene regulation of pro-inflammatory, pro-thrombotic, pro-oxidative stress, and cell permeability. Many impor-tant endothelial cell mechanosensitive genes have been discovered, including KLK10, CCN gene family, NRP2, YAP, TAZ, HIF-1a, NF-kB, FOS, JUN, TFEB, KLF2/KLF4, NRF2, and ID1. Some of them have been intensively studied, whereas the relevant regulatory mechanism of other genes remains unclear. Focusing on these mechanosensitive genes will provide new strategies for therapeutic intervention in atherosclerotic vascular disease. Thus, this article reviews the mechanosensitive genes affecting vascular endothelial cells, including classical pathways and some newly screened genes, and summarizes the latest research progress on their roles in the pathogenesis of atherosclerosis to reveal effective therapeutic targets of drugs and provide new insights for anti-atherosclerosis.(c) 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons. org/licenses/by-nc-nd/4.0/)."

基金机构："National Natural Science Foundation of China [31971242, 12032007]; Chongqing Science and Technology Bureau (China) [cstc2021jsyj-yzysbA0057]; Joint Medical Research Project of Chongqing Science and Technology Bureau and Chongqing Health Commission (China) [2018ZDXM032]"

基金资助正文："This work was supported in part by the National Natural Science Foundation of China (No. 31971242, 12032007) , the Chongqing Science and Technology Bureau (China) (No. cstc2021jsyj-yzysbA0057) , and the Joint Medical Research Project of Chongqing Science and Technology Bureau and Chongqing Health Commission (China) (No. 2018ZDXM032) ."