The nonlinear association between triglyceride glucose-body mass index and femoral neck BMD in nondiabetic elderly men: NHANES 2005-March 2020

作者全名："Xuan, Xiuping; Sun, Rong; Peng, Caibi; Liu, Lijuan; Huang, Tiantian; Huang, Chenghu; Dang, Shaonong; Dang, Shaonong; Dang, Shaonong; Dang, Shaonong"

作者地址："[Xuan, Xiuping] Guangxi Med Univ, Dept Endocrinol, Affiliated Hosp 1, Nanning 530021, Guangxi, Peoples R China; [Sun, Rong] Hubei Univ Med, Taihe Hosp, Dept Ophthalmol, Shiyan 442000, Hubei, Peoples R China; [Peng, Caibi] Bishan Matern & Child Hosp Chongqing, Chongqing 402760, Peoples R China; [Liu, Lijuan; Huang, Tiantian; Huang, Chenghu] Bishan Hosp Chongqing Med Univ, Bishan Hosp Chongqing, Dept Endocrinol, Chongqing 402760, Peoples R China"

通信作者："Huang, CH (通讯作者)，Bishan Hosp Chongqing Med Univ, Bishan Hosp Chongqing, Dept Endocrinol, Chongqing 402760, Peoples R China."

来源：PLOS ONE

ESI学科分类：Multidisciplinary

WOS号：WOS:001150428500020

JCR分区：Q1

影响因子：3.7

年份：2024

卷号：19

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Background The triglyceride glucose-body mass index (TyG-BMI) has been considered a surrogate marker for assessing insulin resistance. We aimed to correlate the TyG-BMI, triglyceride glucose combined with body mass index, with femoral neck bone mineral density (FN BMD) in non-diabetic elderly men.Methods Using data from the National Health and Nutrition Examination Survey (NHANES) database, totally, 1182 eligible men aged >= 50 years without diabetes were included in the current study. Smoothed curves were obtained by a two-piecewise linear regression model and the threshold effects were explored by using a smoothing function.Results TyG-BMI was positive related with and FN BMD with or without adjustment for confounders. However, no typical dose-dependent positive association between TyG-BMI and FN BMD was observed across the TyG-BMI tertiles, indicating a non-linear association. Further analysis by the weighted two-piecewise linear regression model and recursive algorithm suggested that per SD increase in TyG-BMI increased FN BMD by 0.266 gm/cm2 when TyG-BMI lower than 168.20. However, when TyG-BMI is higher than 168.20, FN BMD only increased 0.046 gm/cm2 for per SD increase of TyG-BMI after fully adjustment (OR = 11.258, 95%CI: 6.034, 16.481). Moreover, subgroup analyses showed that higher TyG-BMI levels were related to elevated FN BMD in all groups, suggesting the consistency of the positive association within these stratas.Conclusions This study demonstrated that TyG-BMI is positively associated with FN BMD in a nonlinear fashion among elderly men without diabetes, which may be a reliable marker for the early identification of individuals with lower FN BMD."

基金机构：Chongqing Natural Science Foundation [CSTB2022NSCQ-MSX1096]; Scientific and Technological Project of Chongqing Bishan [BSKJ2021002]

基金资助正文："Chenghu Huang received funding from the Chongqing Natural Science Foundation (No.CSTB2022NSCQ-MSX1096) and the Scientific and Technological Project of Chongqing Bishan (No.BSKJ2021002). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."