Potential impact on using aspirin as the primary prevention of adverse pregnancy outcomes in twins conceived using ART

作者全名："Huang, Dongni; Xie, Yao; Duan, Pingmei; Wang, Jiaxin; Xu, Jiacheng; Qi, Hongbo; Luo, Xin"

作者地址："[Huang, Dongni; Duan, Pingmei; Wang, Jiaxin; Qi, Hongbo] Chongqing Med Univ, Dept Obstet & Gynecol, Women & Childrens Hosp, Chongqing 401147, Peoples R China; [Huang, Dongni; Xu, Jiacheng; Luo, Xin] Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet, Chongqing 400016, Peoples R China; [Huang, Dongni; Xu, Jiacheng; Qi, Hongbo; Luo, Xin] Chongqing Med Univ, Chongqing Key Lab Maternal & Fetal Med, Chongqing 400016, Peoples R China; [Xie, Yao] Maternal & Child Hlth Hosp Shapingba Dist, Chongqing 401331, Peoples R China"

通信作者："Qi, HB (通讯作者)，Chongqing Med Univ, Dept Obstet & Gynecol, Women & Childrens Hosp, Chongqing 401147, Peoples R China.; Luo, X (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet, Chongqing 400016, Peoples R China.; Qi, HB; Luo, X (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Maternal & Fetal Med, Chongqing 400016, Peoples R China."

来源：SCIENTIFIC REPORTS

ESI学科分类：Multidisciplinary

WOS号：WOS:001152222400042

JCR分区：Q1

影响因子：4.6

年份：2024

卷号：14

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："With the development of assisted reproductive technology, the number of twin pregnancies is increasing year by year. Given the increased risk of pregnancy complications associated with twin pregnancies, and the fact that these babies are rare and difficult to obtain through assisted reproductive technology, clinicians urgently require finding effective and safe drugs to improve pregnancy outcomes. Low-dose aspirin can not only promote placental blood supply, but also effectively anti-inflammatory. Whether Low-dose aspirin can effectively reduce the risk of pregnancy complications in this special group needs to be clarified. We therefore retrospectively analyzed 665 twin pregnancies from assisted reproduction technology, grouped according to aspirin use, and followed pregnancy outcomes to assess bleeding risk. Low-dose aspirin was found to be effective in preventing preeclampsia without a significant risk of bleeding. However, aspirin does not prevent specific complication in twin pregnancies and seems to have a better preventive effect only when the mother is under 30, which should alarm clinicians should not blindly using aspirin in this particular group."

基金机构：National Natural Science Foundation of China [82171668]; National Key Research and Development Program of China [2022YFC2704700]

基金资助正文：The funding was provided by The National Natural Science Foundation of China (82171668) and also by National Key Research and Development Program of China (2022YFC2704700).