Diffusion kurtosis imaging reveals abnormal gray matter and white matter development in some brain regions of children with attention-deficit/hyperactivity disorder

作者全名："Tang, Shilong; Liu, Xianfan; Nie, Lisha; Qian, Fangfang; Chen, Wushuang; He, Ling; Yang, Mei"

作者地址："[Tang, Shilong; Liu, Xianfan; Qian, Fangfang; Chen, Wushuang; He, Ling] Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Radiol, Minist Educ Key,Lab Child Dev & Disorders,Children, Chongqing, Peoples R China; [Nie, Lisha] MR Res China, GE Healthcare, Beijing, Peoples R China; [Yang, Mei] Chongqing Med Univ, Treatment Ctr, Dept Neonatal Diag, Childrens Hosp, Chongqing, Peoples R China; [Yang, Mei] Chongqing Med Univ, Childrens Hosp, Dept Radiol, Chongqing 400014, Peoples R China"

通信作者："Yang, M (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Radiol, Chongqing 400014, Peoples R China."

来源：JOURNAL OF NEUROSCIENCE RESEARCH

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001153553100013

JCR分区：Q2

影响因子：4.2

年份：2024

卷号：102

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：attention-deficit hyperactivity disorder; brain; children; diffusion kurtosis imaging; magnetic resonance imaging

摘要："In this study, we explored the application of diffusion kurtosis imaging (DKI) technology in the brains of children with attention-deficit/hyperactivity disorder (ADHD). Seventy-two children with ADHD and 79 age- and sex-matched healthy controls were included in the study. All children were examined by means of 3D T1-weighted image, DKI, and conventional sequence scanning. The volume and DKI parameters of each brain region were obtained by software postprocessing (GE ADW 4.6 workstation) and compared between the two groups of children to determine the imaging characteristics of children with ADHD. The result showed the total brain volume was lower in children with ADHD than in healthy children (p < .05). The gray and white matter volumes in the frontal lobe, temporal lobe, hippocampus, caudate nucleus, putamen, globus pallidus, and other brain regions were lower in children with ADHD than in healthy children (p < .05). The axial kurtosis (Ka), mean kurtosis (MK), fractional anisotropy (FA), and radial kurtosis(Kr) values in the frontal lobe, temporal lobe, and caudate nucleus of children with ADHD were lower than those of healthy children, while the mean diffusivity(MD) and fractional anisotropy of kurtosis (FAK) values were higher than those of healthy children (p < .05). Additionally, the Ka, MK, FA, and Kr values in the frontal lobe, caudate nucleus, and temporal lobe could be used to distinguish children with ADHD (AUC > .05, p < .05). In conclusion, DKI showed abnormal gray matter and white matter development in some brain regions of children with ADHD."

基金机构：Chongqing Municipal Education Commission

基金资助正文：No Statement Available