Atorvastatin exerts dual effects of lesion regression and ovarian protection in the prevention and treatment of endometriosis

作者全名："Qin, Xian; Wang, Qian; Xu, Dongmei; Sun, Yixuan; Xu, Wandong; Wang, Bo; Yang, Zhu; Hao, Lijuan"

作者地址："[Qin, Xian; Wang, Qian; Xu, Dongmei; Sun, Yixuan; Xu, Wandong; Wang, Bo; Hao, Lijuan] Women & Childrens Hosp Chongqing Med Univ, Dept Obstet & Gynecol, Women & Childrens Hosp, Chongqing 401147, Peoples R China; [Qin, Xian; Wang, Qian; Xu, Dongmei; Sun, Yixuan; Xu, Wandong; Wang, Bo; Hao, Lijuan] Chongqing Hlth Ctr Women & Children, Dept Obstet & Gynecol, Chongqing 401147, Peoples R China; [Yang, Zhu] Chongqing Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 2, Chongqing 400010, Peoples R China; [Hao, Lijuan] Chongqing Med Univ, Chongqing Hlth Ctr Women & Children, Dept Obstet & Gynecol, Women & Childrens Hosp, Chongqing 401147, Peoples R China"

通信作者："Hao, LJ (通讯作者)，Chongqing Med Univ, Chongqing Hlth Ctr Women & Children, Dept Obstet & Gynecol, Women & Childrens Hosp, Chongqing 401147, Peoples R China."

来源：EUROPEAN JOURNAL OF PHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001153558500001

JCR分区：Q1

影响因子：4.2

年份：2024

卷号：964

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Endometriosis; Atorvastatin; Ovarian function; Ovarian reserve; Fertility

摘要："Endometriosis is a frequent, chronic, estrogen-dependent and inflammatory gynecological disease leading to pain and infertility. Clinical and metabolic studies reveal that patients with endometriosis are susceptible to hyperlipemia and lipid dysfunction, putting them at ascending risk of cardiovascular diseases. Statins constitute a group of cholesterol-lowering drugs with pleiotropic effects. A plethora of researches have proved their ability to inhibit the growth of ectopic lesions in endometriosis. However, concerns exist about their possible adverse effects on ovarian function. This study aimed to investigate the possible effect of atorvastatin on the ovarian endocrine function and fertility capacity in the prevention and treatment of endometriosis. Here, 5 mg/kg atorvastatin was intraperitoneally injected to the endometriosis mice once a day for consecutive fourteen days during and after the development of endometriotic implants. The results indicated that atorvastatin not only led to regression of the ectopic lesions, but also caused no discernible harm to the ovary for both the preventive and the therapeutic models. In addition, it elicited a protective effect on the ovarian reserve and fertility possibly by reducing inflammation in the ovary. Hence, atorvastatin could be a promising drug for endometriosis prevention and treatment."

基金机构：Hospital Project of Women and Children's Hospital of Chongqing Medical Uni- versity (Chongqing Health Center for Women and Children) [2021YJQN09]; Chongqing Natural Science Foundation of Chongqing Bureau of Science and Technology [CSTB2023NSCQ- BHX0029]

基金资助正文：This work was financially supported by a grant from the Hospital Project of Women and Children's Hospital of Chongqing Medical Uni- versity (Chongqing Health Center for Women and Children) (Grant No. 2021YJQN09) and Chongqing Natural Science Foundation of Chongqing Bureau of Science and Technology (Grant No. CSTB2023NSCQ- BHX0029) .