The connection between epigenetics and gut microbiota-current perspective
作者全名："Yuan, Xingxing; Tan, Yurong; Bajinka, Ousman; Jammeh, Modou L.; Dukureh, Abubakarr; Obiegbusi, Chidera N.; Abdelhalim, Khalid A.; Mohanad, Mahmoud"
作者地址："[Yuan, Xingxing] Heilongjiang Acad Tradit Chinese Med, Dept Gastroenterol, Harbin, Peoples R China; [Yuan, Xingxing] Heilongjiang Univ Chinese Med, Dept Clin Med Coll 1, Harbin, Peoples R China; [Tan, Yurong; Bajinka, Ousman; Mohanad, Mahmoud] Cent South Univ, Dept Med Microbiol, Changsha, Peoples R China; [Tan, Yurong; Bajinka, Ousman; Jammeh, Modou L.] Univ Gambia, Sch Med & Allied Hlth Sci, Dept Med Sci, Banjul, Gambia; [Dukureh, Abubakarr] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Med Sci, Wuhan, Peoples R China; [Obiegbusi, Chidera N.] Chongqing Med Univ, Affiliated Hosp 2, Dept Med Sci, Chongqing, Peoples R China; [Abdelhalim, Khalid A.] Izmir Biomed & Genome Ctr, Ind Res & Dev, Izmir, Turkiye; [Tan, Yurong; Bajinka, Ousman] Cent South Univ, Xiangya Sch Med, Dept Med Microbiol, Changsha 410078, Hunan, Peoples R China"
通信作者："Tan, YR; Bajinka, O (通讯作者)，Cent South Univ, Xiangya Sch Med, Dept Med Microbiol, Changsha 410078, Hunan, Peoples R China."
来源：CELL BIOCHEMISTRY AND FUNCTION
ESI学科分类：MOLECULAR BIOLOGY & GENETICS
WOS号：WOS:001153790300001
JCR分区：Q3
影响因子：2.8
年份：2024
卷号：42
期号：2
开始页：
结束页：
文献类型：Review
关键词：diseases; epigenetic changes; gut microbiota; multi-omics; therapeutic targets
摘要："Both the epigenetic changes and gut microbiota (GM) have attracted a growing interest in establishing effective diagnostics and potential therapeutic strategies for a number of diseases. These disorders include metabolic, central nervous system-related diseases, autoimmune, and gastrointestinal infections (GI). Despite the number of studies, there is no extensive review that connects the epigenetics modifications and GM as biomarkers that could confer effective diagnostics and confer treatment options. To this end, this review hopes to give detailed information on connecting the modifications in epigenetic and GM. An updated and detailed information on the connection between the epigenetics factors and GM that influence diseases are given. In addition, the review showed some associations between the epigenetics to the maternal GM and offspring health. Finally, the limitations of the concept and prospects into this new emerging discipline were also looked into. Although this review elucidated on the maternal diet and response to offspring health with respect to GM and epigenetic modifications, there still exist various limitations to this newly emerging discipline. In addition to integrating complementary multi-omics data, longitudinal sampling will aid with the identification of functional mechanisms that may serve as therapeutic targets. To this end, this review gave a detailed perspective into harnessing disease diagnostics, prevention and treatment options through epigenetics and GM. Dysbiosis of the gut may induce disease and regulate host epigenetic modification. In this review, we elucidate the interrelationship between host epigenetic regulation and gut microbiome changes in a number of diseases."
基金机构：National Natural Science Foundation of China; Excellent Youth Project of Natural Science Foundation of Heilongjiang Province [YQ2022H015]; Postdoctoral Funding of Heilongjiang Province [LBH-Z21218]; [82205007]
基金资助正文："National Natural Science Foundation of China (82205007), Excellent Youth Project of Natural Science Foundation of Heilongjiang Province (No: YQ2022H015), and Postdoctoral Funding of Heilongjiang Province (LBH-Z21218)."
