The maternal hair metabolome is capable of discriminating intrahepatic cholestasis of pregnancy from uncomplicated pregnancy

作者全名："Yin, Nanlin; Jiang, Xiuping; Yu, Muhua; Yang, Yang; Ge, Huisheng; Han, Ting-Li; Qi, Hongbo"

作者地址："[Yin, Nanlin; Ge, Huisheng; Qi, Hongbo] Chongqing Med Univ, Women & Childrens Hosp, Dept Obstet & Gynecol, Chongqing, Peoples R China; [Yin, Nanlin; Jiang, Xiuping] Chongqing Med Univ, Affiliated Hosp 1, Ctr Reprod Med, Chongqing, Peoples R China; [Yu, Muhua; Han, Ting-Li] Chongqing Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Chongqing, Peoples R China; [Yang, Yang] Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet, Chongqing, Peoples R China; [Han, Ting-Li; Qi, Hongbo] Chongqing Med Univ, Joint Int Res Lab Reprod & Dev, Chinese Minist Educ, Chongqing, Peoples R China; [Qi, Hongbo] Chongqing Med Univ, Chongqing Key Lab Maternal & Fetal Med, Chongqing, Peoples R China"

通信作者："Qi, HB (通讯作者)，Chongqing Med Univ, Women & Childrens Hosp, Dept Obstet & Gynecol, Chongqing, Peoples R China.; Han, TL (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Chongqing, Peoples R China.; Han, TL; Qi, HB (通讯作者)，Chongqing Med Univ, Joint Int Res Lab Reprod & Dev, Chinese Minist Educ, Chongqing, Peoples R China.; Qi, HB (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Maternal & Fetal Med, Chongqing, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001155037900001

JCR分区：Q2

影响因子：5.2

年份：2024

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：cholestasis of pregnancy; metabolomics; gas chromatography-mass spectrometry; hair; plasma

摘要："Introduction Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease associated with elevated bile acids in the blood. Diagnosis typically only occurs after the manifestation of clinical symptoms and the metabolic mechanisms underlying its development remain unclear. The aim of this study was to investigate potential specific metabolites and the underlying metabolic changes occurring during the development of ICP in the maternal plasma and hair metabolomes of women diagnosed with either ICP or having a healthy pregnancy. Methods A total of 35 Chinese women with ICP and 42 healthy pregnancies were enrolled in our study. Plasma and hair samples, total bile acid levels (TBA), alanine transaminase levels (ALT), aspartate aminotransferase levels (AST), and additional clinical information were collected during the third trimester. Metabolites from maternal plasma and hair segments collected pre-conception and analyzed using gas chromatography-mass spectrometry (GC-MS). Results Three plasma metabolites (p < 0.05, q < 0.38) and 21 hair metabolites (p < 0.05, q < 0.05) were significantly different between ICP and healthy pregnancies. A combination of the eight most significant hair metabolites in a multivariate receiver operating characteristic curve model showed the best area under the curve (AUC) was 0.885, whereas the highest AUC using metabolites from plasma samples was only 0.74. Metabolic pathway analysis revealed 32 pathways were significantly (p and q values < 0.05) affected in the hair samples of patients with ICP. Pathways associated with glutathione metabolism and ABC transporters were affected. No metabolic pathways were significantly affected in plasma. Discussion Overall, this study showed that the hair metabolome could be more useful than the plasma metabolome for distinguishing ICP from normal pregnancy."

基金机构："National Key Research and Development Program of China [2022YFC2704702]; Key Research Program of Chongqing Science and Technology Bureau [CSTB2022TIAD-KPX0156, CSTC2021JCYJ-MSXMX0213]; Chongqing Medical Scientific Research Project (Joint Project of Chongqing Health Commission and Science and Technology Bureau) [2023GGXM005]; Chongqing Municipal Education Commission [KJZD-K202100407]; National Natural Science Foundation of China [U21A20346]; General Program of National Natural Science Foundation of China [82171662]; National Base for Innovation and Talent Introduction in Maternal and Fetal Medicine; Programme of Introducing Talents of Discipline to Universities [(2016)404]"

基金资助正文："The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by National Key Research and Development Program of China (2022YFC2704702),the Key Research Program of Chongqing Science and Technology Bureau (No. CSTB2022TIAD-KPX0156, CSTC2021JCYJ-MSXMX0213), Chongqing Medical Scientific Research Project (Joint Project of Chongqing Health Commission and Science and Technology Bureau) (2023GGXM005), the Chongqing Municipal Education Commission (KJZD-K202100407), Joint Funds of the National Natural Science Foundation of China (No. U21A20346), General Program of National Natural Science Foundation of China(No. 82171662), and National Base for Innovation and Talent Introduction in Maternal and Fetal Medicine supporting by the Programme of Introducing Talents of Discipline to Universities [(2016)404].r The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by National Key Research and Development Program of China (2022YFC2704702),the Key Research Program of Chongqing Science and Technology Bureau (No. CSTB2022TIAD-KPX0156, CSTC2021JCYJ-MSXMX0213), Chongqing Medical Scientific Research Project (Joint Project of Chongqing Health Commission and Science and Technology Bureau) (2023GGXM005), the Chongqing Municipal Education Commission (KJZD-K202100407), Joint Funds of the National Natural Science Foundation of China (No. U21A20346), General Program of National Natural Science Foundation of China(No. 82171662), and National Base for Innovation and Talent Introduction in Maternal and Fetal Medicine supporting by the Programme of Introducing Talents of Discipline to Universities [(2016)404]."