Tumor necrosis factor-α inhibitor for successful treatment of toxic epidermal necrolysis with severe infection: a case series

作者全名："Peng, Yu-Ting; Xiong, Jian-Xia; Wei, Bin; Li, Hui; Xu, Jing; Chen, Ai-Jun; Wang, Ping"

作者地址："[Peng, Yu-Ting; Xiong, Jian-Xia; Wei, Bin; Li, Hui; Xu, Jing; Chen, Ai-Jun; Wang, Ping] First Affiliated Hosp Chongqing Med Univ, Dept Dermatol, Chongqing, Peoples R China; [Wang, Ping] First Affiliated Hosp Chongqing Med Univ, Dept Dermatol, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Wang, P (通讯作者)，First Affiliated Hosp Chongqing Med Univ, Dept Dermatol, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001155457300001

JCR分区：Q4

影响因子：1.6

年份：2024

卷号：52

期号：1

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结束页：　

文献类型：Article

关键词：Toxic epidermal necrolysis; serious active infection; tumor necrosis factor-alpha inhibitor; etanercept; off-label treatment; case series

摘要："Toxic epidermal necrolysis (TEN) is a rare severe cutaneous adverse reaction that involves more than 30% of the body surface area. TEN can be accompanied by a series of systemic symptoms and has a high risk of death. Tumor necrosis factor (TNF)-alpha inhibitors such as adalimumab and etanercept have been shown to be safe and effective for the treatment of TEN in some cases. However, clinical data on the use of TNF-alpha inhibitors to treat TEN with severe systemic infection are scarce. In the present study, three adult patients who developed TEN with serious active infection were successfully treated with etanercept. One of the three patients had active open pulmonary tuberculosis, and the other two had septicemia and/or fungal sepsis. All patients' skin lesions significantly improved after several days, and none of the patients developed emerging or re-emerging infectious diseases, adverse reactions, or a similar rash during follow-up. TNF-alpha inhibitors may be an effective treatment choice for TEN with severe systemic infection. However, further studies with large samples are still required for validation because clinical experience is limited."

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