Advances in the study of autophagy in breast cancer

作者全名："Yu, Tang; Rui, Liu; Zhao, Jiumei; Li, Ziwei; Ying, Hu"

作者地址："[Yu, Tang; Rui, Liu] Kunming Med Univ, Affiliated Hosp 3, Kunming, Peoples R China; [Yu, Tang] Chongqing Med Univ, Affiliated Hosp 3, Chongqing, Peoples R China; [Zhao, Jiumei] Chongqing Nanchuan Dist Peoples Hosp, Chongqing, Peoples R China; [Li, Ziwei] Chongqing Med Univ, Women & Childrens Hosp, Chongqing Hlth Ctr Women & Children, Chongqing, Peoples R China; [Ying, Hu] Kunming Med Univ, Affiliatied Hosp 2, Kunming, Peoples R China; [Ying, Hu] Dept Clin Larboratory, Kunming, Peoples R China"

通信作者："Ying, H (通讯作者)，Kunming Med Univ, Affiliatied Hosp 2, Kunming, Peoples R China.; Ying, H (通讯作者)，Dept Clin Larboratory, Kunming, Peoples R China."

来源：BREAST CANCER

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001155756300001

JCR分区：Q1

影响因子：4

年份：2024

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：Autophagy; Breast cancer; Molecular mechanism; Autophagy inhibitor; Therapy

摘要："Breast cancer is the most prevalent malignant tumor among women, with a high incidence and mortality rate all year round, which seriously affects women's health. Autophagy, a well-conserved cellular process inherent in eukaryotic organisms, plays a pivotal role in degrading damaged proteins and organelles, recycling their breakdown products to aid cells in navigating stress and gradually restoring homeostatic equilibrium. Recent studies have unveiled the intricate connection between autophagy and breast cancer. Autophagy is a double-edged sword in breast cancer, demonstrating a dual role: restraining its onset and progression on one hand, while promoting its metastasis and advancement on the other. It is also because of this interrelationship between the two that regulation of autophagy in the treatment of breast cancer is now an important strategy in clinical treatment. In this article, we systematically survey the recent research findings, elucidating the multifaceted role of autophagy in breast cancer and its underlying mechanisms, with the aim of contributing new references to the clinical management of breast cancer."

基金机构：Yunnan health training project of high level talents

基金资助正文：No Statement Available